Product image of Ketazed (Ketotifen Hydrogen Fumarate) supplied by GNH India

Ketazed

Active Ingredient:
Ketotifen Hydrogen Fumarate
Origin:
EU

Ketazed (Ketotifen Hydrogen Fumarate)

Ketotifen hydrogen fumarate, the active ingredient in Ketazed, is an antihistamine (mast cell stabilizer) presented as an ophthalmic preparation for ocular use. It is employed to manage allergic conjunctivitis and related seasonal allergic eye conditions in patients requiring topical therapy.

GNH India supplies Ketazed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Horus Pharma

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Indications & Clinical Uses

Ketazed acts on ocular allergic pathways to relieve inflammation and itching associated with allergic eye disease.

  • Allergic conjunctivitis: reduces ocular itching, redness, and tearing.
  • Seasonal allergic eye disease: stabilises mast cells to prevent episodic symptoms during pollen seasons.
  • Vernal keratoconjunctivitis: helps control chronic inflammation and photophobia in severe seasonal forms.

How It Works

  • Ketotifen hydrogen fumarate exerts its effect by blocking histamine H1 receptors on ocular tissues and inhibiting mast cell degranulation. This dual action prevents the release of inflammatory mediators such as histamine, leukotrienes, and prostaglandins, thereby reducing ocular itching, redness, and swelling associated with allergic reactions.

Side Effects

Ketazed may cause ocular and systemic reactions in some patients.

Common Side Effects

  • Burning or stinging sensation upon instillation.
  • Transient blurred vision.
  • Mild eye irritation or redness.
  • Dry eye sensation.
  • Headache.
  • Temporary increased tearing.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) with swelling of eyelids or face.
  • Corneal ulcer or keratitis.
  • Persistent intra‑ocular inflammation.
  • Vision loss.
  • Severe eye pain.
  • Acute hypersensitivity dermatitis around the eye.

Precautions & Warnings

Before using Ketazed, consider the following safety measures.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a physician.
  • Contact lens wearers: avoid use unless advised by an eye specialist.
  • Existing ocular infection: evaluate and treat infection prior to administration.
  • Concomitant ocular medications: assess for possible interactions.
  • Store at below 25°C: keep in the original container, protect from light and moisture.

Avoid Interactions

Ketazed may interact with other ocular or systemic agents.

Major Interactions (Avoid)

  • No major drug interactions have been identified for ocular use of ketotifen.

Moderate Interactions (Monitor Closely)

  • Systemic antihistamines: may increase ocular dryness.
  • Topical corticosteroids: could mask signs of infection.
  • Other mast cell stabilizers: additive effect may increase local irritation.
  • Beta‑blocker eye drops: monitor intra‑ocular pressure if used together.
  • Preservative‑containing drops: may enhance irritation when combined.

Frequently Asked Questions

Ketazed is an ophthalmic preparation containing ketotifen hydrogen fumarate. It is used to treat allergic conjunctivitis and seasonal allergic eye disease by reducing itching, redness, and swelling of the eyes caused by allergic reactions.

Ketotifen hydrogen fumarate blocks histamine H1 receptors on ocular tissues and stabilises mast cells, preventing the release of inflammatory mediators such as histamine, leukotrienes, and prostaglandins. This dual action limits the allergic response and alleviates eye symptoms.

The dosing regimen for Ketazed is determined by the prescribing eye‑care professional. Typically, the recommended frequency and number of drops per eye are specified on the prescription based on the severity of the allergic condition.

Safety data for ketotifen hydrogen fumarate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Ketazed.

To request Ketazed, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ketazed belongs to the antihistamine‑mast cell stabiliser class, offering both immediate histamine blockade and longer‑term mast‑cell stabilization. Compared with pure antihistamine drops, it may provide more sustained symptom control, while it differs from corticosteroid eye drops that are reserved for more severe inflammation due to higher side‑effect potential.

Ketazed should be stored at temperatures below 25 °C, in its original container, protected from light and moisture. Do not freeze the product, and keep it out of reach of children.

Ketazed is applied as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place the prescribed number of drops into the conjunctival sac. The eye should be closed gently for a few seconds to allow absorption.

Serious risks, although rare, include severe allergic reactions such as anaphylaxis, corneal ulceration, and persistent intra‑ocular inflammation. Any sudden worsening of vision, intense eye pain, or swelling should prompt immediate medical attention.

Ketazed should be avoided in individuals with known hypersensitivity to ketotifen or any component of the formulation. Patients with active ocular infections or severe ocular surface disease should consult an eye specialist before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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