Product image of Ketazed (Ketotifen Hydrogen Fumarate) supplied by GNH India

Ketazed

Active Ingredient:
Ketotifen Hydrogen Fumarate
Origin:
EU

Ketazed (Ketotifen Hydrogen Fumarate)

Ketotifen hydrogen fumarate, the active ingredient in Ketazed, is an antihistamine and mast cell stabilizer presented as an ophthalmic solution for ocular (topical) use. It is employed to relieve symptoms of allergic conjunctivitis, seasonal allergic eye disease, and related ocular itching and redness.
GNH India supplies Ketazed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU GMP standards and provides regulatory‑approved batches for global distribution. This includes export to Asia, Africa and the Americas.

Manufacturer / TM Owner

Horus Pharma

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Indications & Clinical Uses

  • Ketazed acts on ocular allergic pathways to control inflammation and histamine‑mediated symptoms.
  • Allergic conjunctivitis: reduces eye redness, itching and watery discharge.
  • Seasonal allergic eye disease: alleviates seasonal flare‑ups of ocular allergy.
  • Ocular itching and redness due to allergy: provides rapid symptom relief for allergy‑induced eye irritation.

How It Works

  • Ketotifen hydrogen fumarate blocks histamine H1 receptors on ocular tissues and stabilises mast cells, preventing the release of inflammatory mediators such as histamine, leukotrienes and cytokines. This dual action reduces vascular permeability, edema and sensory nerve activation in the eye, thereby diminishing allergic signs and symptoms.

Side Effects

Ketazed may cause ocular or systemic adverse reactions; reported events are grouped by frequency.

Common Side Effects

  • Burning or stinging sensation upon instillation.
  • Transient blurred vision.
  • Mild eye irritation or foreign‑body feeling.
  • Temporary hyperemia (redness).
  • Slight tearing.

Serious or Rare Side Effects

  • Allergic reaction with swelling of the eyelids or periorbital area.
  • Severe eye pain or sudden vision changes.
  • Corneal ulceration or keratitis.
  • Persistent intra‑ocular pressure elevation.
  • Anaphylaxis (rare).

Precautions & Warnings

  • When using Ketazed, consider the following precautions to ensure safe and effective therapy.
  • Allergy: Do not use if you have known hypersensitivity to ketotifen or any excipients.
  • Pregnancy: Consult a healthcare professional before use, as safety data are limited.
  • Contact lenses: Avoid wearing contact lenses during treatment unless advised.
  • Symptom monitoring: Discontinue and seek medical advice if symptoms worsen or new eye pain develops.
  • Storage: Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Ketazed can interact with other ophthalmic or systemic agents; awareness of potential interactions helps avoid adverse outcomes.

Major Interactions (Avoid)

  • Concurrent use with other topical antihistamines: may increase local irritation.
  • Systemic antihistamines with sedative properties: may enhance drowsiness.

Moderate Interactions (Monitor Closely)

  • Corticosteroid eye drops: may increase risk of ocular pressure elevation.
  • Contact lens cleaning solutions: may affect drug stability.
  • Systemic MAO inhibitors: theoretical risk of additive antihistaminic effects.

Frequently Asked Questions

Ketazed is an ophthalmic eye‑drop containing ketotifen hydrogen fumarate. It is used to treat allergic eye conditions such as allergic conjunctivitis, seasonal allergic eye disease, and associated ocular itching, redness, and watering.

Ketotifen hydrogen fumarate blocks histamine H1 receptors on the eye and stabilises mast cells, preventing the release of histamine and other inflammatory mediators. This dual action reduces vascular leakage, swelling and nerve irritation that cause allergy‑related eye symptoms.

The dosing regimen is determined by the prescribing clinician. Typically, one drop is instilled in each affected eye two to four times daily, but the exact frequency and duration should follow the prescriber’s instructions.

Safety data for ketotifen hydrogen fumarate in pregnancy and lactation are limited. Women who are pregnant, planning pregnancy, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Ketazed.

To order Ketazed, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Ketazed combines antihistamine and mast‑cell‑stabilising actions, offering both immediate symptom relief and longer‑term control. Compared with single‑action antihistamine drops (e.g., olopatadine) or purely anti‑inflammatory steroids, Ketazed provides a broader mechanism without the steroid‑related risk of intra‑ocular pressure rise.

Ketazed should be stored at room temperature, below 25 °C, in its original container. Keep the bottle tightly closed, protect it from direct light and moisture, and discard any product that appears discoloured or contaminated.

Tilt the head back slightly, pull down the lower eyelid to create a small pocket, and instil the prescribed number of drops into the conjunctival sac. Close the eye gently for a few seconds and avoid blinking excessively. Do not touch the dropper tip to any surface.

Serious adverse events, although rare, include severe eye pain, sudden vision changes, corneal ulceration, marked swelling of the eyelids, and systemic allergic reactions such as anaphylaxis. If any of these occur, discontinue use and seek immediate medical attention.

Ketazed should not be used by individuals with a known hypersensitivity to ketotifen hydrogen fumarate or any of the formulation excipients. Persons with active ocular infections or severe ocular surface disease should consult an eye‑care professional before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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