Product image of Ketesse (Dexketoprofen) supplied by GNH India

Ketesse

Active Ingredient:
Dexketoprofen
Origin:
EU

Ketesse (Dexketoprofen)

Dexketoprofen, the active ingredient in Ketesse, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intramuscular and intravenous use. It treats acute pain, postoperative pain, musculoskeletal pain and dental pain in adult patients, providing rapid analgesia after surgical or traumatic events.

GNH India supplies Ketesse as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

  • Dexketoprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.
  • Acute pain: provides rapid relief of severe short‑term pain.
  • Postoperative pain: helps control discomfort following surgical procedures.
  • Musculoskeletal pain: alleviates pain associated with strains, sprains and arthritis.
  • Dental pain: relieves pain after dental extractions or other oral procedures.

How It Works

  • Dexketoprofen reversibly inhibits both cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, leading to a decrease in prostaglandin synthesis. The reduced prostaglandin levels diminish inflammation, lower peripheral sensitisation of nociceptors, and consequently produce analgesic and antipyretic effects.

Side Effects

Adverse reactions may occur with any NSAID therapy.

Common Side Effects

  • Injection site pain
  • Nausea
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding
  • Severe allergic reaction (anaphylaxis)
  • Renal function decline
  • Cardiovascular thrombotic events

Precautions & Warnings

  • Careful assessment and monitoring are required when using Dexketoprofen injectable.
  • Assess renal function: evaluate baseline creatinine and adjust use in renal impairment.
  • Evaluate hepatic function: monitor liver enzymes, especially in patients with liver disease.
  • Use caution in cardiovascular disease: consider increased risk of thrombotic events.
  • Avoid in known hypersensitivity to NSAIDs or dexketoprofen.
  • Monitor for gastrointestinal ulcer risk: co‑prescribe gastro‑protective agents if needed.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Dexketoprofen may interact with several drug classes.

Major Interactions (Avoid)

  • Warfarin: increased bleeding risk.
  • Other NSAIDs: additive gastrointestinal toxicity.
  • ACE inhibitors: potential reduction in renal perfusion.

Moderate Interactions (Monitor Closely)

  • Diuretics: heightened risk of renal impairment.
  • SSRIs: possible enhancement of bleeding tendency.

Frequently Asked Questions

Ketesse is an injectable formulation of dexketoprofen, an NSAID indicated for the short‑term management of acute pain, postoperative pain, musculoskeletal pain and dental pain in adult patients. It is administered by intramuscular or intravenous injection to provide rapid analgesia.

Dexketoprofen works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins. Lower prostaglandin levels lead to decreased inflammation, reduced peripheral sensitisation of pain receptors, and consequently provide analgesic and antipyretic effects.

The specific dose and frequency of Ketesse are determined by the prescribing clinician based on the severity of pain, the route of administration (intramuscular or intravenous), and the individual patient’s clinical condition. No fixed regimen is provided here.

Safety data for dexketoprofen in pregnancy and lactation are limited, and the product does not have an established pregnancy category. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and under close medical supervision.

To request Ketesse, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Ketesse (dexketoprofen) is the S‑enantiomer of ketoprofen, offering a faster onset of analgesia and potentially lower gastrointestinal side‑effects compared with racemic ketoprofen. Compared with ibuprofen or diclofenac, dexketoprofen provides comparable pain relief at lower doses, but the safety profile remains similar to other NSAIDs.

Ketesse must be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. The vial should remain in its original packaging until use to maintain stability and sterility.

Ketesse is supplied as a sterile injectable solution for intramuscular or intravenous injection. Administration is performed by a qualified healthcare professional, following aseptic technique and the dosage instructions provided by the prescriber.

Serious risks include gastrointestinal ulceration or bleeding, severe allergic reactions such as anaphylaxis, renal impairment, and cardiovascular events like myocardial infarction or stroke. Patients should be monitored closely for signs of these conditions, especially if they have pre‑existing risk factors.

Ketesse should be avoided in patients with known hypersensitivity to dexketoprofen or other NSAIDs, those with active gastrointestinal bleeding or ulcer disease, severe renal or hepatic impairment, and individuals with uncontrolled cardiovascular disease unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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