Ketesse (Dexketoprofen)

Dexketoprofen acts on inflammatory pathways to relieve pain in several clinical settings.

• Moderate to severe acute pain: provides rapid analgesia for intense pain episodes.
• Post‑operative pain: reduces pain after surgical procedures.
• Musculoskeletal pain: alleviates pain associated with injuries or inflammatory conditions.

• Dexketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitisation, leading to decreased pain perception and inflammation at the site of injury.

Adverse reactions may range from mild to serious and should be monitored during therapy.

Common Side Effects

• Nausea: mild to moderate stomach upset.
• Headache: transient cranial discomfort.
• Dizziness: occasional light‑headedness.
• Injection site pain: local discomfort after administration.
• Vomiting: occasional emesis.
• Dyspepsia: indigestion or upper abdominal discomfort.

Serious or Rare Side Effects

• Gastrointestinal bleeding: potentially life‑threatening hemorrhage.
• Renal impairment: reduced kidney function, especially in at‑risk patients.
• Severe allergic reactions: anaphylaxis, skin rash, or angioedema.
• Cardiovascular events: increased risk of thrombotic events.
• Liver enzyme elevation: signs of hepatic stress.
• Hematologic abnormalities: rare blood dyscrasias.

Before initiating therapy, clinicians should evaluate patient‑specific risk factors and monitor for adverse events.

• Assess renal function: adjust use in patients with impaired kidney function.
• Assess hepatic function: avoid in severe liver disease.
• Avoid in known NSAID hypersensitivity: contraindicated for allergic individuals.
• Use caution in cardiovascular disease: consider risk of thrombotic events.
• Monitor for gastrointestinal ulcer risk: especially in patients with prior ulcer history.
• Store at ambient temperature: keep in the original container, protect from moisture and light.

Dexketoprofen may interact with several drug classes; awareness helps prevent harmful effects.

Major Interactions (Avoid)

• Other NSAIDs: additive risk of gastrointestinal bleeding.
• Anticoagulants (e.g., warfarin): increased bleeding tendency.
• SSRIs or SNRIs: heightened risk of GI hemorrhage.
• ACE inhibitors in renal‑compromised patients: possible renal function decline.

Moderate Interactions (Monitor Closely)

• Diuretics: may affect renal clearance.
• Lithium: potential for increased lithium levels.
• Methotrexate: reduced clearance leading to toxicity.
• Corticosteroids: synergistic ulcerogenic effect.
• Antihypertensives: possible reduction in antihypertensive efficacy.