Ketesse (Dexketoprofen)

Dexketoprofen works by reversibly inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the synthesis of prostaglandins that mediate inflammation, pain, and fever. Lower prostaglandin levels diminish peripheral sensitisation of nociceptors, resulting in analgesic and anti‑inflammatory effects.

The specific dose of Ketesse is determined by the prescribing clinician based on the patient’s condition, weight, and clinical response. Healthcare professionals follow local prescribing guidelines and adjust the regimen as needed; patients should not alter the dose without medical advice.

Safety of dexketoprofen in pregnancy and lactation has not been definitively established. It is generally avoided during the first trimester and used only if the potential benefit outweighs the risk. Breastfeeding mothers should consult their physician, as the drug may be excreted in milk.

To order Ketesse, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and any necessary import documentation.

Ketesse (dexketoprofen) is the S‑enantiomer of ketoprofen, offering a faster onset and potentially lower gastrointestinal toxicity compared with non‑selective NSAIDs like ibuprofen or diclofenac. Compared with ketorolac, another injectable NSAID, dexketoprofen provides similar analgesic potency but may have a shorter half‑life, allowing quicker recovery of renal function.

Ketesse must be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. If temporary storage at room temperature is unavoidable, limit exposure to less than 24 hours and return the product to refrigerated conditions promptly.

Ketesse is supplied as an injectable solution for intramuscular or intravenous administration. The injection is performed by a qualified healthcare professional using aseptic technique, typically into a large muscle (e.g., gluteal) or directly into a vein, depending on the clinical situation.

Serious adverse events include gastrointestinal bleeding or ulceration, severe renal impairment, hepatotoxicity, and hypersensitivity reactions such as anaphylaxis. Patients should be monitored for signs of bleeding, sudden loss of kidney function, liver enzyme elevations, or allergic symptoms, and treatment should be stopped immediately if these occur.

Ketesse is contraindicated in patients with known hypersensitivity to dexketoprofen or other NSAIDs, active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, and in those who have experienced asthma exacerbations triggered by NSAIDs. Caution is also advised for individuals on anticoagulant therapy or with uncontrolled hypertension.