Product image of Ketesse (Dexketoprofen) supplied by GNH India

Ketesse

Active Ingredient:
Dexketoprofen
Origin:
EU

Ketesse (Dexketoprofen)

Dexketoprofen, the active ingredient in Ketesse, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for systemic use. It is indicated for the relief of mild to moderate acute pain, including musculoskeletal, post‑operative, dental pain and dysmenorrhea. It provides rapid analgesic effect within 30 minutes of administration.

GNH India supplies Ketesse as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution rooted in the European Union market and compliance with EU regulatory standards.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Dexketoprofen is an NSAID that reduces pain and inflammation by inhibiting cyclooxygenase enzymes.

  • Mild to moderate acute pain: provides analgesia for short‑term pain episodes.
  • Musculoskeletal pain: alleviates pain and stiffness associated with strains, sprains and arthritis.
  • Post‑operative pain: helps control pain following surgical procedures.
  • Dental pain: reduces discomfort after dental extractions or procedures.
  • Dysmenorrhea: eases menstrual‑related cramping and pain.

How It Works

  • Dexketoprofen exerts its effect through non‑selective inhibition of cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes peripheral sensitisation, inflammation and pain signalling, providing rapid analgesic and anti‑inflammatory activity.

Side Effects

Adverse reactions may occur with Dexketoprofen use.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Skin rash: mild erythema or pruritus.

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding: potentially severe hemorrhage.
  • Renal impairment: reduced kidney function or acute kidney injury.
  • Severe hypersensitivity: anaphylaxis, angioedema or bronchospasm.
  • Hepatotoxicity: elevated liver enzymes or liver injury.
  • Cardiovascular thrombotic events: increased risk of myocardial infarction or stroke.

Precautions & Warnings

Before prescribing Dexketoprofen, clinicians should consider several safety aspects.

  • Renal function assessment: evaluate baseline kidney status, especially in elderly patients.
  • Gastro‑intestinal risk: avoid in individuals with a history of ulcer disease or bleeding.
  • Cardiovascular history: use cautiously in patients with known heart disease.
  • Concomitant medications: review for other NSAIDs or anticoagulants.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Dexketoprofen may interact with various medicines, requiring attention to the interaction level.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened hemorrhagic potential.

Moderate Interactions (Monitor Closely):\n- Diuretics: possible reduction in renal perfusion.

  • Lithium: risk of lithium toxicity.
  • Methotrexate: potential for increased methotrexate levels.
  • Corticosteroids: enhanced risk of gastrointestinal ulceration.

Frequently Asked Questions

Ketesse, containing dexketoprofen, is prescribed to manage mild to moderate acute pain such as musculoskeletal injuries, post‑operative discomfort, dental procedures, and dysmenorrhea. It works by reducing inflammation and providing rapid pain relief, making it suitable for short‑term analgesic therapy in adults.

Dexketoprofen blocks both cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for prostaglandin production. By lowering prostaglandin levels, it diminishes inflammation, peripheral sensitisation, and the transmission of pain signals, resulting in faster and effective analgesia.

The exact dose of Ketesse is determined by the prescribing healthcare professional based on the patient’s condition, severity of pain, and individual risk factors. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for dexketoprofen in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Ketesse, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketesse (dexketoprofen) is the S‑enantiomer of ketoprofen, offering a faster onset of analgesia and potentially lower gastrointestinal side‑effects compared with racemic mixtures. Compared with ibuprofen or naproxen, it may provide comparable pain control at lower doses, but individual response varies.

Ketesse should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and heat sources to maintain its stability and potency throughout its shelf life.

Ketesse is taken orally, usually with a glass of water. It can be taken with or without food, but patients with a sensitive stomach may benefit from taking it with meals to reduce gastrointestinal discomfort.

Serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, renal impairment, and cardiovascular events like myocardial infarction or stroke. Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, blood in stool, sudden swelling, or difficulty breathing.

Ketesse should be avoided in individuals with known hypersensitivity to dexketoprofen or other NSAIDs, active gastrointestinal ulcer disease, severe renal or hepatic impairment, uncontrolled hypertension, and in patients taking anticoagulants without close monitoring. A healthcare professional should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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