Product image of Ketesse (Dexketoprofen) supplied by GNH India

Ketesse

Active Ingredient:
Dexketoprofen
Origin:
EU

Ketesse (Dexketoprofen)

Dexketoprofen, the active ingredient in Ketesse, is a non‑steroidal anti‑inflammatory drug (NSAID) presented as an oral tablet for oral use. It provides analgesic and anti‑inflammatory effects for mild to moderate pain, musculoskeletal discomfort, post‑operative pain and dysmenorrhea in adult patients, and is indicated for short‑term management of pain and inflammation.

GNH India supplies Ketesse as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution aligned to EU regulatory standards.

Manufacturer / TM Owner

Menarini International Operations Luxembourg S.A.

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Indications & Clinical Uses

Dexketoprofen is an NSAID that reduces inflammation and pain through cyclooxygenase inhibition.

  • Mild to moderate pain: provides analgesic relief for common aches such as headache, dental pain or minor injuries.
  • Musculoskeletal pain: alleviates discomfort associated with strains, sprains, arthritis and back pain.
  • Post‑operative pain: helps manage pain following surgical procedures.
  • Dysmenorrhea: reduces menstrual cramps and related discomfort.

How It Works

  • Dexketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which decreases the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis leads to diminished inflammation, lowered peripheral sensitisation of nociceptors, and consequently analgesic and antipyretic actions.

Side Effects

Dexketoprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Severe gastrointestinal bleeding: vomiting blood or black, tarry stools.
  • Renal impairment: sudden decrease in urine output or peripheral oedema.
  • Allergic reactions: anaphylaxis, facial swelling or difficulty breathing.

Precautions & Warnings

Before prescribing Dexketoprofen, clinicians should consider several safety factors.

  • Renal function: assess kidney status before initiating therapy.
  • Cardiovascular risk: use cautiously in patients with hypertension or established heart disease.
  • Gastrointestinal history: avoid in individuals with active ulcers or recent gastrointestinal bleeding.
  • Concomitant anticoagulants: monitor closely for increased bleeding tendency.
  • Store at ambient temperature: keep below 25 °C in the original container, protected from moisture.

Avoid Interactions

Dexketoprofen can interact with several medication classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Selective COX‑2 inhibitors: heightened cardiovascular risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: possible reduction in renal function.
  • Diuretics: monitor electrolytes and kidney function.
  • Lithium: may raise serum lithium concentrations, necessitating level checks.

Frequently Asked Questions

Ketesse, containing dexketoprofen, is indicated for the short‑term relief of mild to moderate pain, including musculoskeletal pain such as strains or arthritis, post‑operative discomfort after surgical procedures, and dysmenorrhea, which is painful menstrual cramps.

Dexketoprofen works by non‑selectively blocking cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which reduces the production of prostaglandins. Lower prostaglandin levels diminish inflammation and decrease the sensitisation of pain receptors, providing both analgesic and anti‑inflammatory effects.

The exact dose of Ketesse is determined by the prescribing clinician based on the individual’s condition, age, renal function and other medications. Healthcare professionals follow local prescribing guidelines to select an appropriate strength and dosing interval for each patient.

Safety data for dexketoprofen in pregnancy and lactation are limited. It is generally advised to avoid use unless the potential benefit outweighs the possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To order Ketesse, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketesse (dexketoprofen) is the active enantiomer of ketoprofen and often provides faster onset of analgesia compared with ibuprofen. Both belong to the NSAID class and share similar mechanisms, but dexketoprofen may require lower doses for comparable pain relief, while the overall safety profile remains comparable, requiring similar gastrointestinal and cardiovascular precautions.

Ketesse should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Ketesse is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce the likelihood of gastrointestinal discomfort. Patients should follow the prescriber’s instructions regarding timing and any specific administration guidelines.

The most serious risks include severe gastrointestinal bleeding, ulceration, renal impairment that may lead to reduced urine output or swelling, and rare but life‑threatening allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they notice signs of bleeding, sudden kidney problems, or severe allergic symptoms.

Ketesse should be avoided in individuals with known hypersensitivity to dexketoprofen or any other NSAID, those with active gastrointestinal ulceration or bleeding, severe renal or hepatic impairment, and patients with established cardiovascular disease who are at high risk for thrombotic events unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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