Ketesse (Dexketoprofen)

Dexketoprofen, an NSAID, provides analgesic and anti‑inflammatory effects for several acute pain conditions.

• Mild to moderate acute pain: Reduces pain intensity and improves functional comfort.
• Post‑operative pain: Facilitates postoperative recovery by alleviating surgical site discomfort.
• Dental pain: Controls pain associated with dental procedures and extractions.
• Musculoskeletal pain: Relieves pain from strains, sprains and inflammatory joint conditions.
• Dysmenorrhea: Decreases menstrual cramp severity and associated discomfort.

• Dexketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting reduction in prostaglandin synthesis diminishes peripheral sensitisation of nociceptors, leading to decreased pain perception and inflammation at the site of injury or disease.

Dexketoprofen may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

• Gastro‑intestinal discomfort or dyspepsia.
• Nausea or vomiting.
• Headache.
• Dizziness.
• Mild skin rash or pruritus.
• Transient increase in blood pressure.

Serious or Rare Side Effects

• Gastro‑intestinal ulceration or bleeding.
• Cardiovascular events such as myocardial infarction or stroke.
• Acute renal impairment or failure.
• Severe hypersensitivity reactions, including anaphylaxis.
• Hepatic enzyme elevation or hepatitis.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Before prescribing Dexketoprofen, clinicians should consider several safety aspects.

• Assess renal function: evaluate baseline kidney status before initiating therapy.
• Monitor gastrointestinal risk: avoid in patients with active ulcer disease or a history of GI bleeding.
• Avoid concomitant anticoagulants: increased bleeding risk when combined with warfarin or similar agents.
• Use lowest effective dose: limit duration to the shortest necessary to control pain.
• Pregnancy and lactation: safety not established; consider alternative therapies.
• Store at ambient temperature: keep below 25 °C, in original packaging, protect from moisture.

Dexketoprofen can interact with a variety of medicines, requiring careful management.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): heightened hemorrhage risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce renal function, especially in volume‑depleted patients.
• Diuretics: potential for renal impairment when combined.
• Lithium: NSAIDs may raise lithium serum concentrations, necessitating level monitoring.