Ketesse (Dexketoprofen)

Dexketoprofen is an NSAID that acts on the cyclooxygenase pathway to relieve pain and inflammation.

• Mild to moderate pain: provides rapid analgesia for acute discomfort.
• Musculoskeletal pain: reduces pain and swelling associated with strains, sprains and arthritis.
• Post‑operative pain: helps control pain after surgical procedures.
• Inflammatory conditions: diminishes inflammation in acute inflammatory states.

• Dexketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces peripheral sensitisation of nociceptors, leading to analgesia, and limits the inflammatory cascade, providing anti‑inflammatory benefits.

Dexketoprofen may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

• Gastro‑intestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Mild skin rash or pruritus.
• Elevated liver enzymes (transient).

Serious or Rare Side Effects

• Gastro‑intestinal bleeding or ulceration.
• Severe cardiovascular events such as myocardial infarction or stroke.
• Acute renal failure or worsening of chronic kidney disease.
• Severe skin reactions (Stevens‑Johnson syndrome, toxic epidermal necrolysis).
• Anaphylactic or anaphylactoid reactions.
• Hepatic necrosis or severe hepatitis.

Before prescribing Dexketoprofen, clinicians should evaluate patient‑specific risk factors and monitor for adverse events.

• Gastro‑intestinal risk: assess history of ulcers or bleeding and consider gastro‑protective therapy.
• Cardiovascular safety: review history of heart disease, hypertension or stroke.
• Renal function: monitor creatinine and adjust use in patients with renal impairment.
• Hepatic health: check liver enzymes in patients with liver disease.
• Hypersensitivity: avoid in individuals with known allergy to dexketoprofen or other NSAIDs.
• Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Dexketoprofen can interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Lithium: elevated lithium levels leading to toxicity.
• Methotrexate: reduced clearance and potential toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding risk.

Moderate Interactions (Monitor Closely):\n- Antihypertensives (ACE inhibitors, ARBs, diuretics): possible reduction in antihypertensive effect.

• Corticosteroids: increased risk of gastrointestinal ulceration.
• Oral hypoglycemics: potential alteration of blood glucose control.
• Diuretics: may affect renal function when combined.
• Cyclosporine: increased nephrotoxicity risk.