Ketesse (Dexketoprofen)

Dexketoprofen is an NSAID that reduces pain and inflammation by inhibiting cyclooxygenase enzymes.

• Mild to moderate pain: provides analgesia for general pain conditions.
• Musculoskeletal pain: alleviates pain associated with muscles, joints and soft tissues.
• Post‑operative pain: helps control pain after surgical procedures.
• Dental pain: reduces pain following dental interventions.

• Dexketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which decreases the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis leads to diminished inflammation, pain perception, and fever responses at the site of tissue injury.

Adverse reactions may range from mild to severe and should be monitored during therapy.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness: transient sensation of light‑headedness.
• Rash: mild skin irritation or erythema.
• Elevated liver enzymes: transient increase in hepatic markers.

Serious or Rare Side Effects

• Gastrointestinal ulcer or bleeding: potentially life‑threatening hemorrhage.
• Renal impairment: reduced kidney function or acute kidney injury.
• Severe allergic reactions: anaphylaxis, angioedema, or Stevens‑Johnson syndrome.
• Hepatic dysfunction: hepatitis or liver failure.
• Cardiovascular events: increased risk of myocardial infarction or stroke.

Before prescribing Dexketoprofen, clinicians should evaluate patient‑specific risk factors and monitor for adverse events.

• Assess gastrointestinal risk: review history of ulcers, bleeding disorders, or chronic NSAID use.
• Evaluate renal function: check baseline creatinine and monitor during therapy, especially in the elderly.
• Monitor hepatic status: perform liver function tests if pre‑existing liver disease is present.
• Caution in cardiovascular disease: consider alternative analgesics for patients with recent myocardial infarction or uncontrolled hypertension.
• Avoid in known hypersensitivity: discontinue if signs of severe allergic reaction appear.
• Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Dexketoprofen may interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

• Other NSAIDs or aspirin: heightened risk of gastrointestinal bleeding.
• Anticoagulants (e.g., warfarin, DOACs): increased bleeding tendency.
• Selective COX‑2 inhibitors: additive renal and cardiovascular hazards.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or diuretics: potential reduction in renal function.
• Lithium: NSAIDs can raise lithium serum concentrations.
• Methotrexate: reduced clearance may lead to toxicity.