Ketesse (Dexketoprofen)

Dexketoprofen acts as an NSAID to relieve pain and inflammation in several clinical settings.

• Mild to moderate pain: provides rapid analgesia for everyday pain conditions.
• Musculoskeletal pain: reduces inflammation and discomfort associated with strains, sprains and arthritis.
• Post‑operative pain: helps control pain after surgical procedures.
• Dysmenorrhea: alleviates menstrual cramps and associated uterine pain.

• Dexketoprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, decreasing the synthesis of prostaglandins that mediate inflammation, pain and fever. By reducing prostaglandin levels at the site of tissue injury, it limits the inflammatory response and provides analgesic relief without directly affecting central nervous system pathways.

Adverse reactions may occur with any NSAID and vary in frequency and severity.

Common Side Effects

• Gastro‑intestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Mild skin rash or pruritus.
• Elevated liver enzymes (asymptomatic).

Serious or Rare Side Effects

• Gastro‑intestinal ulceration or bleeding.
• Acute renal impairment or failure.
• Cardiovascular events such as myocardial infarction or stroke.
• Severe skin reactions (Stevens‑Johnson syndrome, toxic epidermal necrolysis).
• Hepatic injury with jaundice.
• Anaphylactic or severe hypersensitivity reactions.

Before prescribing Dexketoprofen, clinicians should consider several safety aspects.

• Renal function assessment: avoid or adjust dose in patients with impaired kidney function.
• Cardiovascular risk evaluation: use cautiously in individuals with a history of heart disease or hypertension.
• Gastro‑intestinal protection: consider gastro‑protective agents for patients at high risk of ulceration.
• Hypersensitivity screening: discontinue immediately if signs of allergic reaction appear.
• Elderly patients: start at the lowest effective dose and monitor closely for adverse events.
• Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Dexketoprofen may interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Corticosteroids: heightened risk of ulceration and bleeding.
• Lithium: possible increase in lithium serum levels.

Moderate Interactions (Monitor Closely)

• Antihypertensive agents (e.g., ACE inhibitors, ARBs): may reduce blood pressure control.
• Methotrexate: potential for increased methotrexate toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): modest increase in bleeding risk.