Ketesse (Dexketoprofen)

Dexketoprofen acts as an NSAID to alleviate pain and reduce inflammation across several clinical settings.

• Musculoskeletal pain: alleviates pain and swelling associated with muscle, joint and back disorders.
• Dental pain: provides rapid relief of pain and inflammation following dental procedures.
• Postoperative pain: reduces postoperative discomfort and inflammatory response after surgery.
• Dysmenorrhea: eases menstrual cramps and associated pelvic pain.
• Acute inflammatory conditions: diminishes inflammation in soft tissue injuries.
• General pain: offers short‑term relief of moderate to severe pain where NSAIDs are appropriate.

• Dexketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis lowers peripheral sensitisation of nociceptors, thereby reducing pain perception and the inflammatory response at the site of tissue injury. Its rapid absorption and high bioavailability contribute to a quick onset of analgesia, typically within 30 minutes after oral administration.

Dexketoprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

• Nausea: mild stomach upset or queasiness.
• Dyspepsia: indigestion or upper abdominal discomfort.
• Headache: transient head pain.
• Dizziness: light‑headed sensation.
• Diarrhoea: loose stools.
• Skin rash: mild erythema or itching.

Serious or Rare Side Effects

• Gastrointestinal bleeding: signs of blood in stool or vomiting blood.
• Peptic ulcer perforation: severe abdominal pain and vomiting.
• Renal impairment: reduced urine output or swelling.
• Severe allergic reaction: hives, swelling of face or throat, difficulty breathing.
• Hepatic dysfunction: jaundice or abnormal liver tests.
• Cardiovascular events: increased risk of heart attack or stroke.

Before prescribing Dexketoprofen, clinicians should evaluate patient risk factors and monitor for potential complications.

• Assess renal function: adjust use in patients with impaired kidney function.
• Evaluate gastrointestinal risk: avoid in individuals with active ulcers or history of bleeding.
• Review cardiovascular history: use cautiously in patients with heart disease or hypertension.
• Check for NSAID hypersensitivity: contraindicated in those with known allergy to NSAIDs.
• Monitor concomitant anticoagulant therapy: increased bleeding risk may require dose adjustment.
• Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Dexketoprofen can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Other NSAIDs: additive risk of gastrointestinal bleeding.
• Anticoagulants (e.g., warfarin): heightened anticoagulant effect and bleeding.
• Selective COX‑2 inhibitors: increased renal and cardiovascular toxicity.
• Corticosteroids: amplified risk of ulceration and bleeding.

Moderate Interactions (Monitor Closely)

• ACE inhibitors: may reduce renal function when combined.
• Diuretics: potential for decreased kidney perfusion.
• Lithium: NSAIDs can raise lithium serum levels.