Ketesse (Dexketoprofen)

Dexketoprofen is used to relieve acute pain by inhibiting inflammatory pathways associated with musculoskeletal, postoperative, dental and other short‑term painful conditions.

• Musculoskeletal pain: provides analgesic relief for acute or chronic musculoskeletal conditions.
• Postoperative pain: reduces pain intensity after surgical procedures.
• Dental pain: alleviates pain following dental extractions or procedures.
• Dysmenorrhea: reduces menstrual cramps and associated pain.
• Acute low back pain: provides rapid analgesia for sudden low back discomfort.
• Rheumatic pain: helps control mild pain in rheumatic disorders.
• Post‑traumatic pain: eases pain after minor injuries.

• Dexketoprofen exerts its effect by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which reduces the synthesis of prostaglandins involved in pain, inflammation and fever. The selective blockade of COX enzymes diminishes peripheral sensitisation of nociceptors, leading to analgesia and anti‑inflammatory activity without directly affecting central nervous system pathways. The rapid onset of action is due to its high bioavailability after oral administration, allowing effective pain control within 30 minutes.

Dexketoprofen may cause adverse reactions, which are classified by frequency and severity.

Common Side Effects

• Nausea: mild to moderate upset stomach.
• Dyspepsia: discomfort or burning in the upper abdomen.
• Headache: transient pain in the head region.
• Dizziness: sensation of light‑headedness or unsteadiness.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration: potentially life‑threatening bleeding in the stomach or intestines.
• Renal impairment: reduced kidney function, especially in at‑risk patients.
• Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Anaphylaxis: rare but severe allergic reaction requiring immediate medical attention.

When prescribing or dispensing Dexketoprofen, consider the following precautions to minimise risk.

• Assess renal function: evaluate kidney status before initiating therapy, especially in elderly patients.
• Assess hepatic function: monitor liver enzymes in patients with pre‑existing liver disease.
• Use lowest effective dose: prescribe the minimal dose needed for pain control.
• Avoid in known hypersensitivity: discontinue if allergic reactions occur.
• Caution with anticoagulants: monitor bleeding risk when combined with warfarin or antiplatelet agents.
• Store at ambient temperature: keep in the original packaging, protect from moisture and heat.

Dexketoprofen can interact with other medicines; some combinations should be avoided while others require careful monitoring.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding risk.

Moderate Interactions (Monitor Closely)

• Diuretics: may reduce renal clearance of dexketoprofen.
• ACE inhibitors or ARBs: potential for reduced renal function.