Ketesse Sl (Dexketoprofen)

Dexketoprofen acts as an analgesic and anti‑inflammatory agent within the NSAID drug class, providing relief across several painful conditions.

• Pain: delivers rapid analgesic relief for acute and chronic pain.
• Musculoskeletal pain: reduces inflammation and discomfort in muscles, joints and connective tissue.
• Postoperative pain: alleviates pain following surgical procedures.
• Dysmenorrhea: eases menstrual cramps and associated discomfort.

• Dexketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which decreases the synthesis of prostaglandins responsible for inflammation, pain, and fever. The reduced prostaglandin levels lead to diminished peripheral sensitization of nociceptors and lower inflammatory responses at the site of tissue injury.

Adverse reactions may occur with any NSAID therapy and vary in frequency and severity.

Common Side Effects

• Nausea: mild to moderate upset stomach.
• Dyspepsia: discomfort or burning in the upper abdomen.
• Headache: transient tension‑type headache.
• Dizziness: occasional light‑headed feeling.
• Diarrhoea: loose stools without blood.
• Abdominal discomfort: mild cramping or bloating.

Serious or Rare Side Effects

• Gastrointestinal ulcer or bleeding: potentially severe bleeding in the stomach or intestines.
• Renal impairment: reduced kidney function, especially in vulnerable patients.
• Hepatic dysfunction: elevated liver enzymes or hepatitis.
• Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Anaphylaxis: rare but life‑threatening allergic reaction.
• Cardiovascular events: increased risk of heart attack or stroke in high‑risk individuals.

Before prescribing Dexketoprofen, clinicians should evaluate patient‑specific risk factors and monitor for adverse outcomes.

• Assess renal function: check creatinine clearance in patients with kidney disease.
• Monitor gastrointestinal risk: avoid in patients with a history of ulcers or bleeding.
• Evaluate cardiovascular history: use cautiously in those with heart disease.
• Use lowest effective dose: limit duration to the shortest necessary period.
• Avoid in known hypersensitivity: discontinue if allergic reactions occur.
• Store at room temperature: keep in the original pack, protect from moisture.

Dexketoprofen may interact with several drug classes, altering efficacy or safety.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Other NSAIDs: additive gastrointestinal toxicity.
• Corticosteroids: heightened ulcer risk.
• ACE inhibitors: potential reduction in renal function.

Moderate Interactions (Monitor Closely)

• Diuretics: may diminish diuretic effect and affect kidney function.
• Methotrexate: possible increase in methotrexate toxicity.
• SSRIs: modestly increased bleeding tendency.