Product image of Ketilept Prolong (Quetiapine Fumarate) supplied by GNH India

Ketilept Prolong

Active Ingredient:
Quetiapine Fumarate
Origin:
EU

Ketilept Prolong (Quetiapine Fumarate)

Quetiapine fumarate, the active ingredient in Ketilept Prolong, is an atypical antipsychotic presented as an oral formulation for oral use. It is prescribed for schizophrenia, bipolar disorder and as adjunct therapy in major depressive disorder, targeting adult patients who require mood stabilization and psychosis control.

GNH India supplies Ketilept Prolong as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Ketilept Prolong, an atypical antipsychotic, is employed across several psychiatric conditions:

  • Schizophrenia: reduces hallucinations, delusions and other psychotic symptoms.
  • Bipolar disorder: stabilises mood during both manic and depressive episodes.
  • Major depressive disorder (adjunct): enhances the effect of standard antidepressants when added to therapy.

How It Works

  • Quetiapine fumarate exerts its therapeutic effect by antagonising serotonin 5‑HT2A, dopamine D2, histamine H1 and adrenergic α1 receptors while acting as a partial agonist at 5‑HT1A receptors. This receptor profile modulates neurotransmission, leading to reduced psychotic symptoms, mood stabilization and improved depressive outcomes.

Side Effects

Ketilept Prolong may cause a range of adverse reactions. Patients should be informed of both common and serious possibilities.

Common Side Effects

  • Sedation or drowsiness
  • Dizziness or orthostatic hypotension
  • Dry mouth
  • Weight gain
  • Constipation
  • Increased appetite

Serious or Rare Side Effects

  • Neuroleptic malignant syndrome
  • Agranulocytosis or severe leukopenia
  • QT interval prolongation and cardiac arrhythmias
  • Suicidal thoughts or behaviour
  • Severe hypotension
  • Hepatic injury or elevated liver enzymes

Precautions & Warnings

When prescribing Ketilept Prolong, clinicians should consider several safety measures.

  • Monitor blood pressure: watch for orthostatic hypotension, especially at treatment initiation.
  • Assess metabolic parameters: track weight, glucose and lipid levels regularly.
  • Evaluate cardiac status: obtain baseline ECG and monitor QT interval in at‑risk patients.
  • Review concomitant CNS depressants: avoid excessive sedation when combined with alcohol or benzodiazepines.
  • Counsel on pregnancy and lactation: discuss limited data and potential risks with women of child‑bearing potential.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ketilept Prolong interacts with several drug classes; careful management is required. Major Interactions (Avoid):\n- Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise quetiapine plasma levels.

  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): may lower efficacy.
  • Other CNS depressants (alcohol, benzodiazepines): can intensify sedation and respiratory depression.
  • Antihypertensive agents: additive hypotensive effect may cause dizziness.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs, SNRIs): increased risk of QT prolongation.
  • Antidiabetic drugs: quetiapine may affect glucose control; monitor blood sugar.
  • Lithium: combined use may raise neurotoxicity risk; observe serum levels.

Frequently Asked Questions

Ketilept Prolong contains quetiapine fumarate and is indicated for the treatment of schizophrenia, for mood stabilization in bipolar disorder (both manic and depressive phases), and as an adjunctive therapy in major depressive disorder when standard antidepressants alone are insufficient.

Quetiapine fumarate works by blocking serotonin 5‑HT2A and dopamine D2 receptors while partially stimulating 5‑HT1A receptors. This combination reduces psychotic symptoms, balances mood, and can improve depressive symptoms by modulating neurotransmitter activity in the brain.

The appropriate dose of Ketilept Prolong is determined individually by a qualified prescriber based on the patient’s diagnosis, severity of symptoms, response to therapy and tolerability. No fixed regimen is provided here; clinicians should follow local prescribing guidelines.

Safety data for quetiapine fumarate in pregnancy and lactation are limited. The prescriber must weigh potential benefits against possible risks to the fetus or infant. If treatment is essential, it may be continued under close medical supervision, but alternative therapies are considered when possible.

To order Ketilept Prolong, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketilept Prolong (quetiapine) offers a broad receptor profile that provides both antipsychotic and mood‑stabilising effects, often with a lower risk of extrapyramidal symptoms compared with some older agents. Compared with risperidone or olanzapine, quetiapine may cause more sedation and weight gain but is frequently chosen for its efficacy in bipolar depression and as an adjunct in major depressive disorder.

Ketilept Prolong should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight. Do not store in bathrooms or near heat sources, and keep out of reach of children.

Ketilept Prolong is taken orally, usually as a whole tablet swallowed with water. It may be taken with or without food, but consistent administration with respect to meals can help maintain stable blood levels. Patients should follow the prescriber’s instructions regarding timing and any dose adjustments.

Serious risks include neuroleptic malignant syndrome, agranulocytosis, significant QT interval prolongation leading to arrhythmias, severe hypotension, and suicidal thoughts, especially during early treatment or dose changes. Patients should seek immediate medical attention if they experience high fever, muscle rigidity, unexplained bruising, palpitations, or worsening depression.

Ketilept Prolong is contraindicated in individuals with known hypersensitivity to quetiapine or any of its excipients, and in patients with uncontrolled narrow‑angle glaucoma. Caution is advised for those with severe cardiovascular disease, hepatic impairment, or a history of seizures. Pregnant or breastfeeding women should only use it if the potential benefit justifies the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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