Product image of Ketisal (Ketotifen Hydrogen Fumarate) supplied by GNH India

Ketisal

Active Ingredient:
Ketotifen Hydrogen Fumarate
Origin:
EU

Ketisal (Ketotifen Hydrogen Fumarate)

Ketotifen hydrogen fumarate, the active ingredient in Ketisal, is an antihistamine; mast cell stabilizer presented as an ophthalmic solution for ocular use. It is employed to relieve symptoms of allergic eye conditions in patients of all ages.

GNH India supplies Ketisal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Horus Pharma

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Indications & Clinical Uses

  • Ketisal is used to manage ocular allergic reactions by targeting histamine‑mediated pathways.
  • Allergic conjunctivitis: reduces itching, redness and swelling of the eye surface.
  • Seasonal allergic eye disease: alleviates symptoms triggered by seasonal allergens.
  • Vernal keratoconjunctivitis: helps control chronic inflammation and discomfort in affected individuals.

How It Works

  • Ketotifen hydrogen fumarate stabilizes mast cells, preventing the release of histamine and other inflammatory mediators. It also competitively antagonizes H1 histamine receptors in ocular tissues, thereby reducing vasodilation, vascular permeability, and sensory nerve activation that contribute to allergic eye symptoms.

Side Effects

Ketisal may cause ocular and systemic reactions in some patients.

Common Side Effects

  • Burning or stinging sensation upon instillation.
  • Temporary blurred vision.
  • Mild eye irritation or redness.
  • Tearing or watery discharge.
  • Headache.
  • Dry eye sensation.

Serious or Rare Side Effects

  • Persistent eye pain or severe irritation.
  • Significant visual acuity changes.
  • Allergic contact dermatitis around the eye.
  • Corneal ulceration.
  • Secondary ocular infection.
  • Systemic hypersensitivity reactions such as rash or swelling.

Precautions & Warnings

Before using Ketisal, consider the following safety measures.

  • Pregnancy: consult a healthcare professional, as safety data are limited.
  • Breastfeeding: discuss potential risks with a physician.
  • Contact lens wearers: remove lenses before instillation and wait before reinserting.
  • Pre‑existing ocular conditions: inform the prescriber of glaucoma, cataract or recent eye surgery.
  • Concomitant eye medications: avoid mixing unless advised by a clinician.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketisal may interact with other ophthalmic agents and systemic drugs.

Major Interactions (Avoid)

  • Concurrent use with other mast cell stabilizers may increase local irritation.
  • Combination with topical anesthetics can exacerbate corneal toxicity.

Moderate Interactions (Monitor Closely)

  • Systemic antihistamines may potentiate sedative effects if systemic absorption occurs.
  • Use with ocular non‑steroidal anti‑inflammatory drugs (NSAIDs) may increase risk of corneal complications.
  • Interaction with beta‑blocker eye drops may affect intra‑ocular pressure control.
  • Caution when combined with corticosteroid eye drops, as additive immunosuppression may occur.

Frequently Asked Questions

Ketisal is an ophthalmic preparation containing ketotifen hydrogen fumarate. It is used to treat allergic eye conditions such as allergic conjunctivitis, seasonal allergic eye disease, and vernal keratoconjunctivitis by relieving itching, redness, and swelling.

Ketotifen hydrogen fumarate works by stabilizing mast cells, which blocks the release of histamine and other inflammatory mediators. It also blocks H1 histamine receptors in ocular tissues, reducing vasodilation and nerve activation that cause allergy symptoms.

The dosing regimen for Ketisal is determined by the prescribing clinician based on the severity of the allergic eye condition, patient age, and response to therapy. Patients should follow the specific instructions provided by their eye care professional.

Safety data for ketotifen hydrogen fumarate in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Ketisal.

To order Ketisal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketisal combines antihistamine activity with mast‑cell stabilization, offering both immediate symptom relief and longer‑term control of allergic inflammation. Compared with pure antihistamine drops, Ketisal may provide more sustained protection against recurrent allergen exposure.

Ketisal should be stored at temperatures below 25 °C in its original packaging. Keep the bottle tightly closed, protect it from moisture and direct sunlight, and discard any product that appears discolored or contains particles.

Ketisal is applied as eye drops. The patient should wash their hands, tilt the head back, pull down the lower eyelid, and instill the prescribed number of drops into the conjunctival sac. The eye should be closed gently for a few seconds to allow absorption.

Serious risks, though rare, include persistent eye pain, significant visual changes, corneal ulceration, and severe allergic reactions such as swelling of the eyelids or systemic rash. Any of these symptoms require immediate medical attention.

Ketisal should be avoided in individuals with known hypersensitivity to ketotifen or any component of the formulation. Patients with active ocular infections, severe corneal disease, or those who have had recent eye surgery should consult an eye specialist before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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