Product image of Ketoconazol Cf (Ketoconazole) supplied by GNH India

Ketoconazol Cf

Active Ingredient:
Ketoconazole
Origin:
EU

Ketoconazol Cf (Ketoconazole)

Ketoconazole, the active ingredient in Ketoconazol Cf, is an azole antifungal presented as a topical formulation for skin use. It is applied to treat fungal infections of the skin and scalp in adults and children when appropriate.

GNH India supplies Ketoconazol Cf as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Centrafarm B.V.

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Indications & Clinical Uses

Ketoconazole is an azole antifungal used to treat superficial fungal infections of the skin and scalp.

  • Tinea corporis (ringworm of the body): reduces fungal growth and clears lesions.
  • Tinea cruris (jock itch): alleviates itching and eliminates the causative dermatophytes.
  • Tinea pedis (athlete’s foot): eradicates the infection and prevents recurrence.
  • Seborrheic dermatitis: controls Malassezia overgrowth and reduces scaling.
  • Pityriasis versicolor: clears pigmentary changes by inhibiting yeast proliferation.
  • Candidal skin infections: treats localized Candida overgrowth on the skin.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a cytochrome P450 isoform essential for converting lanosterol to ergosterol. By blocking ergosterol synthesis, the drug disrupts fungal cell membrane integrity, leading to increased permeability and ultimately fungal cell death.

Side Effects

Ketoconazole may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Burning or stinging at the application site.
  • Pruritus (itching).
  • Erythema or redness of the skin.
  • Dryness or peeling of the treated area.
  • Contact dermatitis.
  • Mild scaling.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis, angioedema).
  • Hepatotoxicity with systemic absorption (rare).
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Photosensitivity reactions.
  • Secondary bacterial infection of the skin.

Precautions & Warnings

Ketoconazole should be used with attention to patient safety and proper handling.

  • Contraindication: Do not use on patients with known hypersensitivity to azole antifungals.
  • Pregnancy: Avoid use unless clearly needed; consult a healthcare professional.
  • Breastfeeding: Caution advised; discuss risks with a physician.
  • Application: Apply a thin layer to clean, dry skin and avoid occlusion unless directed.
  • Interaction: Monitor for systemic absorption when used over large areas or broken skin.
  • Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoconazole may interact with other medications, especially those affecting cytochrome P450 enzymes.

Major Interactions (Avoid)

  • Systemic CYP3A4 inhibitors (e.g., ketoconazole oral, itraconazole): may increase systemic exposure.
  • Hepatotoxic drugs (e.g., isoniazid, methotrexate): heightened risk of liver injury.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may increase skin absorption of ketoconazole.
  • Other topical antifungals: assess for additive irritation.
  • Warfarin: monitor INR if extensive skin application leads to systemic absorption.

Frequently Asked Questions

Ketoconazol Cf is a topical azole antifungal indicated for superficial fungal infections such as tinea corporis, tinea cruris, tinea pedis, seborrheic dermatitis, pityriasis versicolor and localized candidal skin infections. It works by eliminating the fungi that cause these skin conditions.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, preventing the synthesis of ergosterol, a key component of the fungal cell membrane. This disruption weakens the membrane, leading to increased permeability and ultimately fungal cell death.

The dosage of Ketoconazol Cf is determined by the prescribing healthcare professional based on the specific infection, its severity, patient age and the area of skin involved. Patients should follow the prescriber’s instructions and the product label.

Ketoconazol Cf should be used during pregnancy or while breastfeeding only if the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers should be consulted to evaluate safety on an individual basis.

To order Ketoconazol Cf, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoconazol Cf belongs to the azole class, offering broad‑spectrum activity against dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, azoles have a different mechanism targeting ergosterol synthesis and may be preferred for infections involving Malassezia species or when resistance to allylamines is a concern.

Ketoconazol Cf should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Keeping the product at a stable, room‑temperature environment helps maintain its potency and safety.

Apply a thin layer of the cream or lotion to the affected skin area once or twice daily, as directed by a healthcare professional. The skin should be clean and dry before application, and hands should be washed after use to avoid accidental contact with eyes or mucous membranes.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and hepatotoxicity from systemic absorption. Patients should seek immediate medical attention if they experience symptoms like widespread rash, blistering, fever, jaundice or difficulty breathing.

Ketoconazol Cf should not be used by individuals with a known hypersensitivity to ketoconazole or other azole antifungals. It is also contraindicated on extensive broken skin, in patients with severe liver disease, or when used concurrently with certain systemic CYP3A4 inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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