Product image of Ketoconazol Cinfa (Ketoconazole) supplied by GNH India

Ketoconazol Cinfa

Active Ingredient:
Ketoconazole
Origin:
EU

Ketoconazol Cinfa (Ketoconazole)

Ketoconazole, the active ingredient in Ketoconazol Cinfa, is an azole antifungal presented as a topical formulation for skin use. It treats fungal skin infections such as athlete’s foot, ringworm and seborrheic dermatitis in adults and children, and is indicated for a range of dermatological fungal conditions.

GNH India supplies Ketoconazol Cinfa as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing and regulatory support for global healthcare providers and ensuring product quality across markets.

Manufacturer / TM Owner

Laboratorios Cinfa S.A.

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Indications & Clinical Uses

Ketoconazole is an azole antifungal that acts on dermatophyte and yeast infections of the skin.

  • Tinea corporis: reduces lesion size and clears the fungal infection on the body.
  • Tinea cruris: alleviates itching and eliminates the causative fungus in the groin area.
  • Tinea pedis: treats athlete’s foot by eradicating fungal growth on the feet.
  • Seborrheic dermatitis: controls flaking and redness caused by Malassezia species.
  • Pityriasis versicolor: restores normal skin pigmentation by removing the yeast infection.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts the integrity of the fungal cell membrane, leading to increased permeability and ultimately cell death. This mechanism is selective for fungi, sparing human cells that use a different sterol pathway.

Side Effects

Ketoconazol Cinfa may cause local skin reactions.

Common Side Effects

  • Itching: mild to moderate sensation at the application site.
  • Burning: transient warmth or stinging after application.
  • Redness: erythema of the treated area.
  • Dryness: flaking or scaling of the skin.
  • Irritation: discomfort or tenderness.
  • Peeling: superficial skin shedding.

Serious or Rare Side Effects

  • Contact dermatitis: severe allergic skin reaction requiring medical attention.
  • Extensive skin rash: widespread erythema or bullous formation.
  • Systemic absorption leading to hepatic effects: rare but possible with large area use.
  • Anaphylaxis: immediate hypersensitivity reaction, though extremely uncommon.

Precautions & Warnings

Before using Ketoconazol Cinfa, consider the following safety measures.

  • Avoid application on broken skin: may increase systemic absorption.
  • Do not use with occlusive dressings: can enhance irritation.
  • Limit use to prescribed area: avoid excessive coverage.
  • Discontinue if severe irritation occurs: seek medical advice promptly.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ketoconazol Cinfa can interact with other topical or systemic agents.

Major Interactions (Avoid)

  • Concurrent use with other topical antifungals: may increase local irritation.
  • Use with corticosteroid creams on the same area: may mask infection signs.

Moderate Interactions (Monitor Closely)

  • Extensive skin damage may increase systemic absorption, potentially interacting with oral azoles.
  • Co‑application with photosensitizing agents: may raise risk of sunburn.
  • Use with moisturizers containing alcohol: may affect drug penetration.

Frequently Asked Questions

Ketoconazol Cinfa is a topical azole antifungal indicated for superficial fungal infections of the skin, including tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athlete’s foot), seborrheic dermatitis, and pityriasis versicolor. It works by eliminating the fungi that cause these dermatological conditions.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for synthesising ergosterol, a key component of the fungal cell membrane. Inhibiting ergosterol production weakens the membrane, leading to increased permeability and fungal cell death, thereby clearing the infection.

The amount of Ketoconazol Cinfa to apply, the frequency of application, and the duration of therapy are determined by the prescribing healthcare professional based on the specific infection, its severity, the patient’s age, and the area of skin involved. Patients should follow the prescriber’s instructions exactly.

Safety data for topical ketoconazole in pregnancy and lactation are limited. Because the risk cannot be ruled out, it should be used only if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their clinician.

To order Ketoconazol Cinfa, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the team provides pricing, availability, shipping details and any necessary import documentation.

Ketoconazol is an azole class antifungal, offering broad‑spectrum activity against dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, ketoconazole has a similar efficacy for many skin infections but may be chosen for its anti‑inflammatory properties in seborrheic dermatitis. Choice depends on infection type, patient tolerance and prescriber preference.

Ketoconazol Cinfa should be stored at room temperature, below 25 °C (77 °F). Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use to maintain stability.

Apply a thin layer of the cream or gel to the affected skin area once or twice daily, as directed by the prescriber. Gently rub it in until it disappears, and wash hands before and after application unless the hands are the treatment site. Avoid covering the treated area with airtight dressings unless instructed.

Although rare, serious adverse reactions can include severe contact dermatitis, extensive skin rash, or systemic effects such as hepatic toxicity if large skin areas are treated and significant absorption occurs. Patients should stop use and seek medical attention if they notice swelling, jaundice, or any signs of an allergic reaction.

Ketoconazol Cinfa should not be used by individuals with a known hypersensitivity to ketoconazole or any component of the formulation. It is also contraindicated on extensive broken skin, in patients with severe liver disease, or in those who have experienced severe reactions to other topical azole antifungals.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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