Product image of Ketoconazol Klinge (Ketoconazole) supplied by GNH India

Ketoconazol Klinge

Active Ingredient:
Ketoconazole
Origin:
EU

Ketoconazol Klinge (Ketoconazole)

Ketoconazole, the active ingredient in Ketoconazol Klinge, is an azole antifungal presented as a topical preparation for skin application. It treats superficial fungal infections such as tinea corporis, tinea cruris, tinea pedis, seborrheic dermatitis and pityriasis versicolor in both adults and children. It is commonly prescribed by dermatologists.

GNH India supplies Ketoconazol Klinge as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to multiple regions.

Manufacturer / TM Owner

Aenova Ip Gmbh

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Indications & Clinical Uses

Ketoconazole is used topically to treat fungal skin conditions by inhibiting the growth of dermatophytes and yeasts.

  • Tinea corporis: clears the infection and reduces redness and scaling.
  • Tinea cruris: alleviates itching and erythema in the groin area.
  • Tinea pedis: resolves foot fungus and diminishes moisture‑related irritation.
  • Seborrheic dermatitis: controls flaking and inflammation on scalp and face.
  • Pityriasis versicolor: eliminates pigment‑changing yeast and restores normal skin colour.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a cytochrome P450 isoform required for conversion of lanosterol to ergosterol. By blocking ergosterol synthesis, the drug disrupts the fungal cell membrane structure, increasing permeability and leading to cell death. The topical formulation delivers the active compound directly to the skin surface, concentrating the effect on superficial organisms while limiting systemic absorption.

Side Effects

Topical ketoconazole may cause local skin reactions, ranging from mild irritation to rare severe hypersensitivity.

Common Side Effects

  • Burning sensation: transient heat at the application site.
  • Itching: mild pruritus during treatment.
  • Redness: erythema around the treated area.
  • Dryness: flaky skin after repeated use.
  • Stinging: brief sharp discomfort on contact.
  • Scaling: mild flaking of the skin.

Serious or Rare Side Effects

  • Allergic contact dermatitis: widespread rash and swelling.
  • Severe skin eruption: bullous or exfoliative dermatitis.
  • Photosensitivity: increased sunburn risk on treated skin.
  • Systemic absorption leading to hepatotoxicity: rare liver enzyme elevation.
  • Angioedema: swelling of lips, tongue or face.

Precautions & Warnings

When using Ketoconazol Klinge, consider the following precautions to ensure safe and effective therapy.

  • Assess for hypersensitivity: verify no known allergy to ketoconazole or azole antifungals.
  • Limit application area: avoid extensive skin coverage to reduce systemic absorption.
  • Avoid occlusion: do not cover treated skin with airtight dressings unless directed.
  • Monitor liver function: consider periodic testing if large amounts are applied over prolonged periods.
  • Caution in children: use under pediatric supervision and follow prescriber guidance.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoconazole can interact with other topical or systemic agents; awareness of these interactions helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Concurrent oral ketoconazole: may increase systemic exposure and toxicity.
  • Potent corticosteroid creams: can enhance percutaneous absorption of ketoconazole.
  • Systemic azole antifungals (e.g., itraconazole, fluconazole): additive antifungal effect may increase risk of liver injury.

Moderate Interactions (Monitor Closely)

  • Alcohol‑based skin products: may increase irritation at the application site.
  • Sunscreens or UV‑protective lotions: may reduce ketoconazole efficacy if applied immediately after.
  • Antihistamine creams: monitor for altered skin response.

Frequently Asked Questions

Ketoconazol Klinge is a topical azole antifungal indicated for superficial fungal skin infections such as tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athlete's foot), seborrheic dermatitis, and pityriasis versicolor. It works by eliminating the fungi that cause these conditions, helping to relieve symptoms like redness, scaling, and itching.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for converting lanosterol to ergosterol, a key component of the fungal cell membrane. Inhibiting this step disrupts membrane integrity, leading to increased permeability and ultimately fungal cell death. The topical form delivers the drug directly to the skin where the infection resides.

The exact amount and frequency of application are set by the prescribing healthcare professional. Dosage depends on factors such as the type and severity of the infection, the size of the affected area, patient age, and any underlying health conditions. Patients should follow the prescriber’s instructions and not alter the regimen without medical advice.

Safety data for topical ketoconazole during pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss the use of Ketoconazol Klinge with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Ketoconazol Klinge. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Both ketoconazole and clotrimazole belong to the azole class and are effective against many dermatophytes and yeasts. Ketoconazole often has a broader spectrum, covering some resistant strains, and may be preferred for seborrheic dermatitis and pityriasis versicolor. Choice of agent depends on the specific infection, local resistance patterns, patient tolerance and prescriber preference.

Ketoconazol Klinge should be stored at room temperature, typically below 25 °C (77 °F). Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use to maintain stability.

Clean and gently dry the affected skin area before use. Apply a thin layer of Ketoconazol Klinge to the lesion(s) and surrounding skin, usually once or twice daily as directed by the prescriber. Rub gently until the product is absorbed, and wash hands after application unless the hands are being treated.

Although rare, serious adverse reactions can include allergic contact dermatitis, severe skin eruptions such as bullous dermatitis, photosensitivity, and systemic effects like hepatotoxicity if large amounts are absorbed. Patients should seek immediate medical attention if they notice widespread rash, swelling of the face or lips, or signs of liver dysfunction such as jaundice.

Ketoconazol Klinge should be avoided in individuals with a known hypersensitivity to ketoconazole, other azole antifungals, or any component of the formulation. It is also contraindicated for patients who require systemic azole therapy concurrently, as additive toxicity may occur. Children under the age recommended by the prescriber should not use the product without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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