Ketoconazol Ratiopharm (Ketoconazole)

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for synthesising ergosterol, a key component of fungal cell membranes. Inhibiting this pathway disrupts membrane integrity, leading to fungal cell death and clearance of the infection.

The dosage and frequency are determined by the prescribing clinician based on the infection type, severity, and patient factors. Typically, a thin layer is applied to the affected area once or twice daily for a prescribed period.

Safety data for topical ketoconazole during pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoconazole belongs to the imidazole class and is effective against a broad range of dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, ketoconazole has a wider spectrum but may cause more local irritation. Choice depends on the pathogen, site of infection and patient tolerance.

Store the product at room temperature, below 25 °C, in its original packaging. Protect it from moisture, excessive heat and direct sunlight. Keep the container tightly closed when not in use to maintain product stability.

Apply a thin layer of the cream or gel to clean, dry skin on the affected area. Gently rub it in until it disappears. Follow the prescribing clinician’s instructions regarding frequency and duration of treatment.

Although rare, serious adverse reactions can include severe allergic responses such as angioedema, Stevens‑Johnson syndrome, toxic epidermal necrolysis, and significant liver toxicity if systemic absorption occurs. Discontinue use and seek immediate medical attention if any of these symptoms develop.

Patients with known hypersensitivity to ketoconazole or any component of the formulation should avoid use. It is also contraindicated on severely damaged or broken skin, near the eyes, and in individuals where systemic absorption could pose a risk, such as those with severe liver disease.