Product image of Ketoconazol Slavia (Ketoconazole) supplied by GNH India

Ketoconazol Slavia

Active Ingredient:
Ketoconazole
Origin:
EU

Ketoconazol Slavia (Ketoconazole)

Ketoconazole, the active ingredient in Ketoconazol Slavia, is a azole antifungal presented as a topical preparation for skin use. It treats fungal skin infections such as dermatophyte infections, seborrheic dermatitis and pityriasis versicolor in patients of all ages.
GNH India supplies Ketoconazol Slavia as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Slavia Pharm Srl

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Indications & Clinical Uses

Ketoconazole is an azole antifungal that acts on fungal skin infections.

  • Dermatophyte infections: reduces fungal growth and clears lesions.
  • Seborrheic dermatitis: controls Malassezia overgrowth and alleviates scaling and redness.
  • Pityriasis versicolor: eliminates the causative yeast and restores normal skin pigmentation.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts fungal cell membrane integrity, leading to increased permeability and ultimately cell death. This mechanism is specific to fungi, sparing human cells.

Side Effects

Ketoconazole may cause local skin reactions and, rarely, systemic effects.

Common Side Effects

  • Burning sensation at the application site.
  • Itching or pruritus.
  • Redness or erythema.
  • Dryness or flaking of the skin.
  • Stinging or tingling.
  • Mild irritation.

Serious or Rare Side Effects

  • Allergic contact dermatitis.
  • Severe skin reactions such as Stevens‑Johnson syndrome.
  • Hepatotoxicity (systemic absorption in extensive use).
  • Photosensitivity.
  • Secondary bacterial infection of the treated area.

Precautions & Warnings

When using Ketoconazol Slavia, consider the following precautions.

  • Apply only to intact skin: avoid open wounds or mucous membranes.
  • Avoid contact with eyes: rinse immediately if accidental exposure occurs.
  • Do not use on large body areas for prolonged periods without medical supervision.
  • Discontinue use and seek medical advice if severe irritation or allergic reaction develops.
  • Keep out of reach of children: store securely.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoconazol Slavia may interact with other topical agents and systemic medications.

Major Interactions (Avoid)

  • Concurrent use with other topical azole antifungals may increase local irritation.
  • Application over areas treated with corticosteroids can enhance steroid absorption and systemic effects.

Moderate Interactions (Monitor Closely)

  • Use with other skin irritants (e.g., chemical peels) may exacerbate dermatitis.
  • Systemic azole drugs (e.g., oral ketoconazole, itraconazole) may increase overall azole exposure.
  • Co‑administration with photosensitizing agents may raise risk of sunburn.

Frequently Asked Questions

Ketoconazol Slavia is a topical azole antifungal indicated for dermatophyte infections (such as athlete's foot and ringworm), seborrheic dermatitis, and pityriasis versicolor. In each case the medication works to eliminate the causative fungi, relieving symptoms like scaling, redness, and discoloration.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of fungal cell membranes. Without ergosterol, the membrane becomes defective, leading to increased permeability and fungal cell death, thereby clearing the infection.

The dosage of Ketoconazol Slavia is determined by the prescribing healthcare professional based on the specific condition, severity, and patient factors. The prescriber will provide instructions on how much product to apply, the frequency, and the duration of treatment.

Safety data for topical ketoconazole during pregnancy and lactation are limited. Healthcare providers usually weigh the potential benefits against any unknown risks before prescribing. Patients who are pregnant, planning pregnancy, or breastfeeding should discuss use with their clinician.

To request Ketoconazol Slavia, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoconazol Slavia belongs to the azole class, which inhibits ergosterol synthesis. Compared with allylamine agents such as terbinafine, azoles have a broader spectrum against yeasts like Malassezia but may cause more local irritation. Choice of therapy depends on the pathogen, infection site, patient tolerance and clinician preference.

Ketoconazol Slavia should be stored at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

The medication is applied topically to the affected skin area. Clean and dry the skin, then spread a thin layer of the product as directed by the prescriber, usually once or twice daily. Wash hands after application and avoid covering the treated area with occlusive dressings unless advised.

Serious but rare risks include severe allergic reactions such as contact dermatitis, Stevens‑Johnson syndrome, and systemic toxicity like hepatotoxicity if significant absorption occurs. Patients should stop use and seek immediate medical attention if they notice extensive rash, blistering, fever, or signs of liver dysfunction.

Ketoconazol Slavia should not be used on broken skin, mucous membranes, or the eyes. Individuals with a known hypersensitivity to ketoconazole or any component of the formulation should avoid it. Patients with extensive liver disease should consult a physician before using any ketoconazole product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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