Product image of Ketoconazol Tis Farmaceutic (Ketoconazole) supplied by GNH India

Ketoconazol Tis Farmaceutic

Active Ingredient:
Ketoconazole
Origin:
EU

Ketoconazol Tis Farmaceutic (Ketoconazole)

Ketoconazole, the active ingredient in Ketoconazol Tis Farmaceutic, is an imidazole antifungal presented as a topical formulation for skin application. It is used to treat fungal skin infections such as tinea corporis, tinea cruris, tinea pedis, seborrheic dermatitis, and pityriasis versicolor in adults and children.

GNH India supplies Ketoconazol Tis Farmaceutic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance, regulatory compliance and reliable logistics. Our distribution network ensures timely delivery to diverse healthcare settings.

Manufacturer / TM Owner

Tis Farmaceutic Sa

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Indications & Clinical Uses

Ketoconazole is an imidazole antifungal that acts on dermatophyte and yeast infections of the skin.

  • Tinea corporis: reduces fungal growth and promotes resolution of body ringworm lesions.
  • Tinea cruris: alleviates itching and clears fungal infection in the groin area.
  • Tinea pedis: treats athlete’s foot by eliminating dermatophyte colonisation on the feet.
  • Seborrheic dermatitis: controls Malassezia‑related scalp and facial flaking.
  • Pityriasis versicolor: restores normal skin pigmentation by eradicating yeast overgrowth.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts fungal cell membrane integrity, leading to increased permeability and ultimately cell death, while sparing human cells that use a different sterol pathway.

Side Effects

Topical ketoconazole may cause local skin reactions.

Common Side Effects

  • Burning or stinging sensation at the application site.
  • Itching or mild erythema.
  • Dryness or scaling of the treated skin.
  • Redness or mild irritation.

Serious or Rare Side Effects

  • Severe allergic reaction such as angio‑edema.
  • Contact dermatitis with extensive blistering.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hepatotoxicity (rare with extensive use).
  • Photosensitivity leading to exaggerated sunburn.

Precautions & Warnings

Before using, consider the following safety points.

  • Avoid use on broken skin: may increase systemic absorption.
  • Do not apply to mucous membranes: irritation risk.
  • Limit exposure to sunlight: potential photosensitivity.
  • Discontinue if severe irritation occurs: seek medical advice.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ketoconazole can interact with other topical or systemic agents.

Major Interactions (Avoid)

  • Concurrent use with oral ketoconazole: risk of additive hepatotoxicity.
  • Use with potent corticosteroid creams: may mask infection signs.

Moderate Interactions (Monitor Closely)

  • Co‑application with other antifungal creams: may increase local irritation.
  • Alcohol‑based skin products: may enhance drug absorption.
  • Phototoxic agents: increase risk of skin reactions.

Frequently Asked Questions

Ketoconazol Tis Farmaceutic is a topical antifungal indicated for the treatment of superficial fungal skin infections such as tinea corporis (body ringworm), tinea cruris (jock itch), tinea pedis (athlete’s foot), seborrheic dermatitis and pityriasis versicolor. It works by eliminating the fungi that cause these conditions.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for synthesising ergosterol, a key component of the fungal cell membrane. Inhibiting ergosterol production weakens the membrane, leading to increased permeability and ultimately fungal cell death.

The specific dosing regimen for Ketoconazol Tis Farmaceutic is determined by the prescribing healthcare professional based on the infection type, severity, patient age and skin condition. The prescriber will provide detailed instructions on the amount to apply and frequency of use.

Safety data for topical ketoconazole in pregnancy and lactation are limited. Healthcare providers usually weigh the potential benefits against any possible risks before prescribing. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative treatments with their clinician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoconazole belongs to the imidazole class, which is effective against a broad range of dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, ketoconazole offers a similar spectrum but may be preferred for its anti‑inflammatory properties in seborrheic dermatitis. Choice depends on infection type, resistance patterns and patient tolerance.

Store the product at room temperature, preferably below 25 °C. Keep it in the original packaging, protect it from moisture, excessive heat and direct sunlight. Ensure the container is tightly closed to maintain product stability.

The medication is applied topically to the affected skin area. Clean and dry the skin, then spread a thin layer of the cream or ointment over the lesion as directed by the prescriber, usually once or twice daily, and continue for the prescribed duration.

Serious adverse reactions, though rare, include severe allergic responses such as angio‑edema, extensive contact dermatitis, Stevens‑Johnson syndrome or toxic epidermal necrolysis, and systemic hepatotoxicity with extensive use. Patients should seek immediate medical attention if they notice swelling, blistering, jaundice or other severe symptoms.

Individuals with a known hypersensitivity to ketoconazole, other imidazole antifungals, or any formulation components should avoid using the product. It should also be avoided on extensive broken skin, mucous membranes, or in patients with a history of severe drug reactions without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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