Product image of Ketoconazole Arrow (Ketoconazole) supplied by GNH India

Ketoconazole Arrow

Active Ingredient:
Ketoconazole
Origin:
EU

Ketoconazole Arrow (Ketoconazole)

Ketoconazole, the active ingredient in Ketoconazole Arrow, is an imidazole antifungal presented as a topical formulation for skin application. It treats fungal skin infections such as dermatophytosis, seborrheic dermatitis and pityriasis versicolor in patients of various ages.

GNH India supplies Ketoconazole Arrow as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Arrow Generiques

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Indications & Clinical Uses

Ketoconazole Arrow is an imidazole antifungal used to manage common superficial fungal infections.

  • Dermatophytosis (tinea corporis, cruris, pedis): reduces fungal growth and clears skin lesions.
  • Seborrheic dermatitis: alleviates scaling, redness and itching of affected areas.
  • Pityriasis versicolor: restores normal skin pigmentation by eradicating Malassezia species.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts fungal cell membrane integrity, leading to impaired growth and eventual cell death of susceptible dermatophytes and yeasts.

Side Effects

Ketoconazole Arrow may cause local skin reactions.

Common Side Effects

  • Burning sensation: mild to moderate discomfort at the application site.
  • Itching: transient pruritus during treatment.
  • Redness: mild erythema of the treated area.
  • Dryness: temporary skin dryness or flaking.
  • Scaling: superficial skin scaling.
  • Stinging: brief stinging upon application.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives or difficulty breathing.
  • Contact dermatitis: intense rash or blistering.
  • Stevens‑Johnson syndrome: rare but life‑threatening skin eruption.
  • Toxic epidermal necrolysis: extremely rare severe skin detachment.
  • Systemic absorption effects: unlikely but may include liver enzyme alterations.
  • Secondary infection: bacterial infection of compromised skin.

Precautions & Warnings

Before using Ketoconazole Arrow, consider the following precautions.

  • Allergy assessment: avoid if known hypersensitivity to ketoconazole or other imidazoles.
  • Extent of infection: limit use to superficial skin infections; do not apply to large body surface areas without medical advice.
  • Open wounds: do not apply to broken skin or mucous membranes.
  • Concomitant topical steroids: monitor for increased irritation when used together.
  • Pregnancy and lactation: consult a healthcare professional; use only if benefits outweigh potential risks.
  • Store at below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoconazole Arrow can interact with other topical agents and systemic medications.

Major Interactions (Avoid)

  • Systemic azole antifungals: concurrent use may increase systemic ketoconazole exposure.
  • Topical corticosteroids: may enhance skin irritation.
  • Phototoxic agents: increased risk of photosensitivity reactions.

Moderate Interactions (Monitor Closely)

  • Other topical antifungals: assess for additive irritation.
  • Warfarin: monitor INR if extensive skin absorption is suspected.
  • Hepatotoxic drugs: observe liver function if systemic absorption occurs.

Frequently Asked Questions

Ketoconazole Arrow is a topical imidazole antifungal indicated for the treatment of superficial fungal skin infections, including dermatophytosis (such as tinea corporis, cruris and pedis), seborrheic dermatitis, and pityriasis versicolor. It works by eliminating the causative fungi on the skin surface.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for synthesising ergosterol, a key component of fungal cell membranes. Inhibiting this pathway disrupts membrane integrity, halting fungal growth and leading to cell death.

The dosage regimen for Ketoconazole Arrow is determined by the prescribing healthcare professional based on the specific infection, severity, patient age and skin area involved. The prescriber will provide instructions on the amount to apply and the duration of therapy.

Safety data for topical ketoconazole during pregnancy and lactation are limited. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and always under the guidance of a qualified healthcare provider.

To order Ketoconazole Arrow, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other topical azoles such as clotrimazole or miconazole, ketoconazole offers a broad spectrum against dermatophytes and Malassezia species and is often preferred for seborrheic dermatitis. Choice of therapy depends on the specific pathogen, site of infection, patient tolerance and local resistance patterns.

Store Ketoconazole Arrow at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the tube tightly closed when not in use and out of reach of children.

Apply a thin layer of the cream or gel to the affected skin area once or twice daily, as directed by the prescriber. Gently rub it in until fully absorbed, and wash hands after application unless the hands are being treated.

Serious adverse reactions are rare but may include severe allergic responses such as anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis. Patients should seek immediate medical attention if they develop widespread rash, blistering, swelling of the face or difficulty breathing.

Ketoconazole Arrow should not be used by individuals with a known hypersensitivity to ketoconazole, other imidazole antifungals, or any component of the formulation. It is also contraindicated on broken skin, mucous membranes, or in patients where systemic absorption could pose a risk without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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