Ketoconazole Crescent Pharma (Ketoconazole)

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for converting lanosterol to ergosterol, a critical component of the fungal cell membrane. Inhibiting this step disrupts membrane formation, leading to loss of cell integrity, inhibition of fungal growth, and ultimately cell death of susceptible dermatophytes and yeasts.

The dosage and duration of treatment are determined by the prescribing healthcare professional based on the specific infection, its severity, the patient’s age and overall health. The prescriber will provide detailed instructions on how much product to apply and how often.

Safety data for topical ketoconazole during pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After the request, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any required import documentation.

Ketoconazole belongs to the azole class, which inhibits ergosterol synthesis. Compared with allylamine agents such as terbinafine, azoles generally have a broader spectrum against yeasts like Malassezia but may be less potent against certain dermatophytes. Choice of therapy depends on the pathogen, infection site, patient tolerance and local resistance patterns.

Store the product at room temperature, below 25 °C, in its original packaging. Keep it away from excess moisture, direct sunlight and heat sources. Ensure the container is tightly closed when not in use to maintain product stability.

Apply a thin layer of the cream or lotion to the affected skin area once or twice daily, as directed by the prescriber. Gently rub it in until it disappears. Wash hands before and after application, and avoid contact with eyes, mucous membranes and broken skin unless instructed otherwise.

Although rare, serious adverse reactions can include severe allergic responses such as angioedema or anaphylaxis, extensive contact dermatitis, and life‑threatening skin conditions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience swelling of the face, lips, tongue, or a widespread rash with blistering.

Individuals with a known hypersensitivity to ketoconazole, other azole antifungals, or any component of the formulation should avoid using the product. It should also be avoided on open wounds, severely inflamed or broken skin, and in patients with a history of severe drug reactions unless a healthcare professional determines that benefits outweigh the risks.