Product image of Ketoconazole Eg (Ketoconazole) supplied by GNH India

Ketoconazole Eg

Active Ingredient:
Ketoconazole
Origin:
EU

Ketoconazole Eg (Ketoconazole)

Ketoconazole, the active ingredient in Ketoconazole Eg, is an imidazole antifungal presented as a topical formulation for cutaneous use. It treats superficial fungal infections of the skin and scalp by inhibiting sterol synthesis, which compromises fungal cell membranes. The product is suitable for adult and pediatric patients with appropriate medical supervision.

GNH India supplies Ketoconazole Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide.

Manufacturer / TM Owner

Eg Labo Laboratoires Eurogenerics

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Indications & Clinical Uses

Ketoconazole Eg is an imidazole antifungal that targets dermatophyte and yeast infections of the skin and scalp.

  • Tinea corporis: clears ring‑shaped lesions and reduces itching.
  • Tinea cruris: resolves groin area fungal infection and alleviates redness.
  • Tinea pedis: treats athlete's foot, improving scaling and discomfort.
  • Seborrheic dermatitis: reduces flaking and erythema on scalp and face.
  • Pityriasis versicolor: eliminates pigmentary changes caused by Malassezia species.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts the integrity of the fungal cell membrane, leading to increased permeability and ultimately cell death, thereby resolving the infection.

Side Effects

Ketoconazole Eg may cause local skin reactions.

Common Side Effects

  • Itching: mild to moderate pruritus at the application site.
  • Burning sensation: transient warmth or stinging after application.
  • Redness: localized erythema.
  • Dryness or scaling: mild desquamation of treated skin.
  • Irritation: occasional mild discomfort.

Serious or Rare Side Effects

  • Severe allergic reaction: swelling, hives, or difficulty breathing.
  • Contact dermatitis: intense inflammation and blistering.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis: rare but life‑threatening skin eruptions.
  • Systemic absorption leading to hepatic effects (extremely rare with topical use).

Precautions & Warnings

Before using Ketoconazole Eg, consider the following precautions:

  • Avoid application on broken or inflamed skin: may increase irritation.
  • Discontinue if severe redness or swelling occurs: seek medical advice.
  • Keep away from eyes and mucous membranes: rinse thoroughly if contact happens.
  • Do not use on children under 2 years without physician guidance.
  • Do not combine with other topical antifungals unless directed: may affect efficacy.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoconazole Eg can interact with other agents when used concurrently.

Major Interactions (Avoid)

  • Systemic azole antifungals (e.g., oral ketoconazole, fluconazole): risk of additive systemic toxicity.
  • Warfarin or other anticoagulants (if systemic absorption occurs): potential increase in bleeding risk.

Moderate Interactions (Monitor Closely)

  • Topical corticosteroids: may reduce antifungal effectiveness.
  • Skin care products containing alcohol or astringents: could enhance irritation.
  • Hair dyes or chemical treatments applied to the same area: monitor for increased skin sensitivity.

Frequently Asked Questions

Ketoconazole Eg is indicated for the topical treatment of superficial fungal infections such as tinea corporis (ringworm), tinea cruris (jock itch), tinea pedis (athlete's foot), seborrheic dermatitis, and pityriasis versicolor. It helps clear lesions, reduce scaling, and relieve associated itching.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for synthesizing ergosterol, a key component of the fungal cell membrane. Inhibiting this pathway weakens the membrane, causing increased permeability and ultimately leading to fungal cell death.

The dosing regimen for Ketoconazole Eg is determined by the prescribing healthcare professional based on the infection type, severity, patient age, and treatment area. The prescriber will specify the amount to apply, frequency, and duration of therapy.

Safety data for topical ketoconazole during pregnancy and lactation are limited. Healthcare providers usually weigh the benefits against potential risks before prescribing. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative treatments with their clinician.

To order Ketoconazole Eg, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoconazole belongs to the imidazole class, whereas clotrimazole is an azole with a slightly different spectrum. Both are effective against dermatophytes and yeasts, but ketoconazole may have broader activity against certain resistant strains. Choice of agent depends on infection type, physician preference, and patient tolerance.

Store Ketoconazole Eg at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Apply a thin layer of the cream or gel to the affected skin area once or twice daily, as directed by the prescriber. Gently rub it in until it disappears, and wash hands before and after application to avoid accidental contact with eyes or other mucous membranes.

Although rare, serious adverse reactions can include severe allergic responses such as swelling, hives, or difficulty breathing, as well as extensive skin reactions like Stevens‑Johnson syndrome or toxic epidermal necrolysis. If any of these occur, discontinue use immediately and seek emergency medical care.

Ketoconazole Eg should be avoided in individuals with known hypersensitivity to ketoconazole or any component of the formulation. It is also not recommended for use on extensive broken skin, in very young children without medical advice, or in patients who have experienced severe reactions to topical azole antifungals.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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