Product image of Ketoderm (Ketoconazole) supplied by GNH India

Ketoderm

Active Ingredient:
Ketoconazole
Origin:
EU

Ketoderm (Ketoconazole)

Ketoconazole, the active ingredient in Ketoderm, is an azole antifungal presented as a topical formulation for skin use. It treats fungal skin infections such as tinea and seborrheic dermatitis in patients requiring topical therapy.

GNH India supplies Ketoderm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eg Labo Laboratoires Eurogenerics

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Indications & Clinical Uses

Ketoconazole acts on dermatophyte and yeast infections of the skin, reducing fungal proliferation.

  • Tinea corporis: reduces fungal growth and alleviates scaling and itching.
  • Tinea cruris: clears infection and diminishes redness and discomfort.
  • Tinea pedis: eliminates foot fungus and relieves associated irritation.
  • Seborrheic dermatitis: controls Malassezia overgrowth, decreasing flaking and erythema.
  • Pityriasis versicolor: eradicates yeast causing discoloration and restores normal skin tone.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts the integrity of the fungal cell membrane, leading to increased permeability and ultimately cell death, thereby clearing the infection.

Side Effects

Ketoconazole may cause local skin reactions.

Common Side Effects

  • Burning sensation at the application site.
  • Itching or pruritus.
  • Redness or erythema.
  • Dryness or peeling of the skin.
  • Stinging or tingling feeling.
  • Mild irritation or rash.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., angioedema, anaphylaxis).
  • Extensive skin rash or dermatitis.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Systemic absorption leading to hepatotoxicity (very rare with topical use).

Precautions & Warnings

When using Ketoderm, consider the following safety measures.

  • Avoid application on broken or inflamed skin: may increase irritation.
  • Do not apply near eyes or mucous membranes: risk of severe irritation.
  • Discontinue use if severe redness or swelling occurs: seek medical advice.
  • Consult a physician before using other topical medications concurrently: potential additive irritation.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Ketoderm may interact with other agents applied to the skin or absorbed systemically.

Major Interactions (Avoid)

  • Concurrent use with other azole antifungals: may increase systemic absorption and toxicity.
  • Use with oral ketoconazole therapy: risk of additive hepatotoxicity.

Moderate Interactions (Monitor Closely)

  • Application under occlusive dressings: enhances absorption, monitor for irritation.
  • Co‑application with potent topical corticosteroids: may mask signs of infection.
  • Use with other irritant dermatological products: increase risk of local adverse reactions.

Frequently Asked Questions

Ketoderm is a topical antifungal medication indicated for the treatment of superficial fungal skin infections such as tinea corporis, tinea cruris, tinea pedis, seborrheic dermatitis, and pityriasis versicolor. It works by eliminating the fungi that cause these conditions, helping to relieve symptoms like itching, scaling, and redness.

Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, which is essential for synthesising ergosterol, a key component of the fungal cell membrane. Disruption of ergosterol production compromises membrane integrity, leading to fungal cell death and clearance of the infection.

The dosage of Ketoderm is determined by the prescribing healthcare professional based on the specific infection, its severity, and the patient’s condition. The prescriber will provide instructions on the amount to apply, frequency, and duration of treatment.

Safety data for topical ketoconazole in pregnancy and lactation are limited. Healthcare providers should evaluate the potential benefits against any possible risks before prescribing Ketoderm to pregnant or nursing individuals. Patients should discuss their situation with a qualified professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Ketoderm. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoderm’s active ingredient, ketoconazole, belongs to the azole class and offers broad‑spectrum activity against dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, ketoconazole may be preferred for infections involving Malassezia species, like seborrheic dermatitis, while terbinafine is often chosen for nail infections.

Ketoderm should be stored at room temperature, below 25 °C, in its original packaging. Protect the product from excessive moisture, direct sunlight, and extreme temperatures to maintain its stability and effectiveness.

Ketoderm is applied topically to the affected skin area. Clean and dry the skin before use, then spread a thin layer of the product over the lesion as directed by the prescriber, typically once or twice daily for the prescribed duration.

Serious risks, though rare, include severe allergic reactions such as angioedema or anaphylaxis, extensive skin rash, Stevens‑Johnson syndrome, and, in exceptional cases, systemic toxicity like hepatotoxicity if significant absorption occurs. Immediate medical attention is required if these symptoms develop.

Ketoderm should not be used by individuals with known hypersensitivity to ketoconazole or any component of the formulation. It is also contraindicated on severely damaged, inflamed, or broken skin, and should be avoided in patients with a history of severe allergic skin reactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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