Ketofall (Ketotifen Hydrogen Fumarate)

• Ketofall, an antihistamine eye drop, is used to manage allergic eye disease by stabilizing mast cells and blocking histamine.
• Allergic conjunctivitis: reduces itching, redness and tearing caused by allergic inflammation.
• Seasonal allergic eye disease: alleviates symptoms triggered by pollen or seasonal allergens.
• Eye itching and redness due to allergy: provides rapid relief of discomfort and visual disturbance.

• Ketotifen hydrogen fumarate acts by stabilizing mast cells, preventing the release of inflammatory mediators such as histamine, leukotrienes and prostaglandins. It also competitively blocks histamine H1 receptors on ocular tissues, thereby diminishing the vascular and neural responses that produce itching, redness and swelling in allergic eye disease.

Ketofall may cause ocular and systemic reactions, most of which are mild and transient.

Common Side Effects

• Stinging or burning sensation on instillation.
• Temporary blurred vision.
• Mild eye irritation or foreign‑body sensation.
• Transient redness of the conjunctiva.
• Headache.
• Dryness of the ocular surface.

Serious or Rare Side Effects

• Severe allergic reaction (angio‑edema, anaphylaxis).
• Persistent eye pain or swelling.
• Vision loss or sudden decrease in visual acuity.
• Corneal ulcer or keratitis.
• Persistent photophobia.
• Intra‑ocular pressure elevation.

• Before using Ketofall, consider the following safety measures.
• Assess hypersensitivity: confirm no known allergy to ketotifen or related antihistamines.
• Evaluate ocular infection: avoid use if active bacterial, viral or fungal eye infection is present.
• Monitor contact lens wearers: advise removal of lenses before instillation and for a short period after.
• Pregnancy and lactation: use only if the prescriber deems benefits outweigh potential risks.
• Avoid driving or operating machinery if transient visual blur occurs.
• Store at room temperature: keep in the original container, protect from light and moisture.

Ketofall may interact with other agents that affect ocular or systemic histamine pathways.

Major Interactions (Avoid)

• Systemic antihistamines (e.g., diphenhydramine): may increase cumulative antihistaminic effect.
• MAO inhibitors: potential for enhanced central nervous system sedation.
• Other mast cell stabilizers: additive ocular irritation.

Moderate Interactions (Monitor Closely)

• Topical ophthalmic non‑steroidal anti‑inflammatory drugs (NSAIDs): monitor for increased irritation.
• Preservative‑containing eye drops: assess for cumulative preservative toxicity.
• Contact lens solutions with high acidity or preservatives: may exacerbate discomfort.