Product image of Ketoisdin (Ketoconazole) supplied by GNH India

Ketoisdin

Active Ingredient:
Ketoconazole
Origin:
EU

Ketoisdin (Ketoconazole)

Ketoconazole, the active ingredient in Ketoisdin, is an imidazole antifungal presented as a vaginal formulation for local use. It treats vulvovaginal candidiasis in adult women by targeting fungal cells within the vaginal mucosa.

GNH India supplies Ketoisdin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Isdin, S.A.

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Indications & Clinical Uses

Ketoisdin, an imidazole antifungal, is used to treat fungal infections of the vaginal tract.

  • Vulvovaginal candidiasis: reduces yeast overgrowth and alleviates associated symptoms such as itching, discharge, and irritation.

How It Works

  • Ketoconazole inhibits fungal sterol (ergosterol) synthesis by blocking the enzyme lanosterol 14α‑demethylase, a key step in the conversion of lanosterol to ergosterol. This disruption compromises the integrity of the fungal cell membrane, leading to impaired growth and eventual cell death of susceptible yeasts.

Side Effects

Ketoconazole vaginal therapy may cause local and systemic adverse reactions.

Common Side Effects

  • Vaginal irritation or burning sensation
  • Itching at the application site
  • Increased vaginal discharge
  • Unpleasant odor
  • Mild redness or swelling
  • Dryness of the vaginal mucosa

Serious or Rare Side Effects

  • Allergic reaction (rash, hives, swelling)
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Hepatotoxicity (rare with topical use)
  • Systemic hormonal effects
  • Persistent vaginal ulceration
  • Secondary bacterial infection

Precautions & Warnings

Before using Ketoisdin, consider the following safety measures.

  • Confirm diagnosis: Ensure the infection is caused by Candida species.
  • Pregnancy: Discuss use with a healthcare professional; safety data are limited.
  • Breastfeeding: Evaluate risk versus benefit with a clinician.
  • Hepatic impairment: Use with caution in patients with liver disease.
  • Concomitant topical agents: Avoid applying other vaginal medications simultaneously.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Ketoconazole may interact with other medications; monitor accordingly.

Major Interactions (Avoid)

  • Systemic azole antifungals (e.g., oral fluconazole) – increased risk of toxicity.
  • CYP3A4 substrates with narrow therapeutic index (e.g., certain statins) – potential for elevated plasma levels.

Moderate Interactions (Monitor Closely)

  • Hormonal contraceptives – possible reduction in efficacy.
  • Warfarin – may enhance anticoagulant effect.
  • Rifampin – may decrease ketoconazole concentrations.
  • Immunosuppressants (e.g., cyclosporine) – monitor drug levels.

Frequently Asked Questions

Ketoisdin is a vaginal formulation containing ketoconazole, an imidazole antifungal. It is indicated for the treatment of vulvovaginal candidiasis, helping to eliminate yeast overgrowth and relieve symptoms such as itching, discharge, and irritation.

Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, which is essential for synthesizing ergosterol, a key component of the fungal cell membrane. Disruption of ergosterol production weakens the membrane, leading to impaired fungal growth and cell death.

The dosing regimen for Ketoisdin is determined by the prescribing healthcare professional based on the specific product formulation and the severity of the infection. Patients should follow the prescriber’s instructions and the product label.

Safety data for ketoconazole use during pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Ketoisdin.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ketoisdin delivers ketoconazole locally to the vaginal area, offering targeted therapy with minimal systemic exposure. Compared with oral azoles, it may reduce systemic side effects while providing effective eradication of Candida species. Choice of therapy depends on infection severity, patient preference, and clinician judgment.

Store Ketoisdin at room temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight, and extreme temperatures to maintain its stability and efficacy.

Ketoisdin is applied intravaginally according to the prescriber’s instructions, typically using a pre‑filled applicator. The patient should lie down for a few minutes after application to allow proper distribution of the medication.

Serious risks, though rare, include severe allergic reactions such as rash, hives, or swelling, and rare systemic effects like hepatotoxicity. Patients should seek immediate medical attention if they experience signs of a serious reaction.

Ketoisdin should be avoided in individuals with known hypersensitivity to ketoconazole or any component of the formulation. It is also not recommended for patients with severe liver disease or those who are currently using other topical azole antifungals without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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