Ketomag (Ketoprofen)

Ketoprofen is an NSAID that reduces pain and inflammation in several musculoskeletal and acute conditions.

• Pain: provides analgesic relief for mild to moderate pain.
• Inflammation: diminishes inflammatory response in acute injuries.
• Musculoskeletal disorders: alleviates symptoms of osteoarthritis and rheumatoid arthritis.

• Ketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis leads to decreased inflammation, pain perception, and fever.

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

• Gastrointestinal upset: nausea, dyspepsia, abdominal pain.
• Headache and dizziness.
• Skin rash or pruritus.
• Mild elevation of liver enzymes.
• Transient renal function changes.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Severe renal impairment or acute kidney injury.
• Hepatotoxicity with marked liver enzyme rise.
• Anaphylactic or severe allergic reactions.
• Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Increased risk of cardiovascular thrombotic events.

Before using Ketomag, consider the following safety measures.

• Assess gastrointestinal risk: avoid in patients with active ulcers or history of GI bleeding.
• Monitor renal function: use caution in those with impaired kidney function.
• Evaluate hepatic status: periodic liver tests are advisable.
• Use the lowest effective dose for the shortest duration needed.
• Avoid in individuals with known hypersensitivity to ketoprofen or other NSAIDs.
• Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Ketoprofen can interact with several drug classes; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Corticosteroids: heightened ulcer risk.
• ACE inhibitors or ARBs: possible renal function decline.
• Lithium: elevated lithium serum levels.

Moderate Interactions (Monitor Closely):\n- Diuretics: may reduce renal perfusion.

• Methotrexate: decreased clearance, potential toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): modest increase in bleeding.
• Antihypertensives: possible reduction in blood pressure control.
• Oral hypoglycemics: may affect glucose control.