Product image of Ketonal Active (Ketoprofen) supplied by GNH India

Ketonal Active

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal Active (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal Active, is a nonsteroidal anti‑inflammatory drug presented as an oral dosage form for systemic use. It is employed to relieve pain and reduce inflammation in conditions such as arthritis and musculoskeletal disorders.

GNH India supplies Ketonal Active as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Gmbh

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Indications & Clinical Uses

  • Ketoprofen acts on inflammatory pathways and is indicated for several painful and inflammatory conditions.
  • Rheumatoid arthritis: reduces joint pain, swelling and stiffness.
  • Osteoarthritis: alleviates chronic joint discomfort and improves mobility.
  • Musculoskeletal pain: provides relief for strains, sprains and back pain.
  • Post‑operative pain: helps control acute pain after surgical procedures.

How It Works

  • Ketoprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels diminish inflammation, pain signaling, and fever responses, producing its analgesic and anti‑inflammatory effects throughout the body.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort such as nausea or dyspepsia.
  • Headache or dizziness.
  • Mild skin rash or itching.
  • Elevated blood pressure.
  • Fluid retention or mild edema.

Serious or Rare Side Effects

  • Peptic ulcer disease or gastrointestinal bleeding.
  • Severe hypersensitivity reactions, including anaphylaxis.
  • Hepatotoxicity or elevated liver enzymes.
  • Renal impairment or acute kidney injury.
  • Cardiovascular events such as myocardial infarction or stroke.

Precautions & Warnings

  • When using Ketoprofen, consider the following safety measures.
  • Avoid use in patients with active peptic ulcer disease: risk of gastrointestinal bleeding.
  • Monitor renal function in individuals with pre‑existing kidney disease.
  • Assess cardiovascular risk in patients with hypertension or heart disease.
  • Use caution in elderly patients: higher susceptibility to adverse effects.
  • Avoid concurrent use with other NSAIDs or anticoagulants unless medically justified.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoprofen can interact with several drug classes, requiring attention to avoid harmful effects.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened gastrointestinal bleeding.
  • ACE inhibitors or diuretics: potential reduction in renal function.
  • Lithium: increased lithium serum concentrations.
  • Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Corticosteroids: increased ulcer risk.
  • Diabetic medications: possible alteration of blood glucose control.
  • Antihypertensives: may diminish antihypertensive effect.
  • Oral hypoglycemics: potential for reduced efficacy.

Frequently Asked Questions

Ketonal Active contains ketoprofen, an NSAID that is commonly prescribed to manage pain and inflammation associated with rheumatoid arthritis, osteoarthritis, musculoskeletal injuries, and acute postoperative pain. It helps reduce swelling, stiffness, and discomfort in these conditions.

Ketoprofen works by blocking the cyclooxygenase (COX‑1 and COX‑2) enzymes, which are essential for producing prostaglandins. By lowering prostaglandin levels, it diminishes inflammation, pain signaling, and fever, providing therapeutic relief in inflammatory disorders.

The appropriate dose of Ketonal Active is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and overall health status. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Ketoprofen, like other NSAIDs, is generally avoided during the third trimester of pregnancy because it may affect fetal cardiovascular function. Its safety in early pregnancy and while breastfeeding is not well established, so a healthcare provider should evaluate the risks and benefits before use.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoprofen offers analgesic and anti‑inflammatory potency comparable to ibuprofen and naproxen, but it may have a slightly faster onset of action. Its side‑effect profile is similar to other non‑selective NSAIDs, with gastrointestinal and cardiovascular considerations that must be weighed against alternative agents.

Ketonal Active should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, heat and direct sunlight, and ensure the container is tightly closed to maintain stability.

Ketonal Active is taken orally, usually with a full glass of water. It can be taken with or without food, but patients who experience stomach upset may benefit from taking it with meals or an antacid, as advised by their prescriber.

Serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis, renal impairment, and increased cardiovascular events like heart attack or stroke. Patients should seek immediate medical attention if they notice signs of bleeding, severe rash, or chest pain.

Ketonal Active should be avoided by individuals with a known hypersensitivity to ketoprofen or other NSAIDs, active peptic ulcer disease, severe heart failure, uncontrolled hypertension, and those in the third trimester of pregnancy. Consultation with a healthcare professional is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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