Ketonal Duo (Ketoprofen)

Ketoprofen acts as an NSAID to reduce inflammation and pain in several musculoskeletal disorders.

• Mild to moderate pain: provides analgesia for everyday aches and injuries.
• Musculoskeletal pain: alleviates pain associated with strains, sprains and backache.
• Osteoarthritis: reduces joint inflammation and improves mobility.
• Rheumatoid arthritis: helps control inflammatory joint pain and swelling.

• Ketoprofen non‑selectively inhibits cyclooxygenase enzymes COX‑1 and COX‑2, decreasing the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels reduce inflammation, pain signaling, and fever, producing the therapeutic anti‑inflammatory and analgesic effects characteristic of NSAIDs.

Ketoprofen may cause a range of adverse reactions, from mild to serious.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Skin rash or pruritus.
• Elevated liver enzymes.

Serious or Rare Side Effects

• Gastrointestinal ulceration or bleeding.
• Acute renal impairment or failure.
• Severe skin reactions such as Stevens‑Johnson syndrome.
• Anaphylactic or anaphylactoid reactions.
• Hepatotoxicity with jaundice.
• Increased risk of cardiovascular events (e.g., myocardial infarction).

When prescribing or dispensing Ketonal Duo, consider the following safety measures.

• Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
• Monitor renal function: use caution in those with impaired kidney function.
• Evaluate cardiovascular status: limit use in patients with established heart disease.
• Use the lowest effective dose for the shortest duration needed.
• Avoid in individuals with known hypersensitivity to ketoprofen or other NSAIDs.
• Store at ambient temperature: keep in the original pack, protect from moisture.

Ketonal Duo can interact with several medicines; awareness of the interaction level helps manage risk.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Corticosteroids: heightened ulcer risk.
• Lithium: elevated lithium serum concentrations.
• Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: possible reduction in antihypertensive effect and renal function.

• Diuretics: may impair renal perfusion.
• Digoxin: potential increase in serum levels.
• Cyclosporine: enhanced nephrotoxicity.
• Oral hypoglycemics: may affect blood glucose control.