Ketonal Duo (Ketoprofen)

Ketoprofen acts as an NSAID to reduce pain and inflammation in several musculoskeletal and inflammatory disorders.

• Mild to moderate pain: provides analgesic relief for acute and chronic pain conditions.
• Osteoarthritis: decreases joint pain and improves functional mobility.
• Rheumatoid arthritis: reduces inflammatory swelling and joint discomfort.
• Musculoskeletal pain: alleviates strain‑related discomfort and inflammation.
• General inflammation: lowers tissue swelling and erythema associated with inflammatory processes.

• Ketoprofen reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 (COX‑1/COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it diminishes peripheral sensitisation of nociceptors and limits the inflammatory cascade, resulting in analgesic, antipyretic, and anti‑inflammatory effects.

Ketoprofen may cause a range of adverse reactions, from mild discomfort to serious medical events.

Common Side Effects

• Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
• Headache: mild to moderate tension‑type headache.
• Dizziness: transient light‑headedness or vertigo.
• Skin rash: mild erythematous eruption.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulceration: potentially life‑threatening hemorrhage.
• Renal impairment: acute kidney injury or worsening of chronic renal disease.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

When prescribing or dispensing Ketoprofen, consider the following safety measures.

• Assess gastrointestinal risk: evaluate history of ulcers or bleeding before use.
• Monitor renal function: check serum creatinine and urine output in at‑risk patients.
• Use lowest effective dose: limit exposure to the minimum dose needed for symptom control.
• Avoid in known hypersensitivity: discontinue if allergic reactions occur.
• Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Ketoprofen can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Other NSAIDs (e.g., ibuprofen): additive gastrointestinal toxicity.
• Corticosteroids (e.g., prednisone): heightened ulcer risk.

Moderate Interactions (Monitor Closely)

• Diuretics (e.g., furosemide): possible reduction in renal clearance.
• Methotrexate: potential for increased methotrexate toxicity.