Product image of Ketonal Forte (Ketoprofen) supplied by GNH India

Ketonal Forte

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal Forte (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal Forte, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for systemic use. It reduces pain, inflammation and swelling associated with musculoskeletal conditions and is commonly prescribed for adults experiencing acute or chronic discomfort.

GNH India supplies Ketonal Forte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand through reliable logistics networks consistently.

Manufacturer / TM Owner

Lek Pharmaceuticals D.D. Ljubljana

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Indications & Clinical Uses

Ketoprofen is an NSAID that alleviates pain and inflammation across several musculoskeletal and arthritic conditions.

  • Pain: Provides analgesic relief for acute and chronic pain states.
  • Inflammation: Reduces swelling and erythema in inflammatory disorders.
  • Osteoarthritis: Improves joint function and decreases discomfort in degenerative joint disease.
  • Rheumatoid arthritis: Helps control pain and inflammation associated with autoimmune joint inflammation.
  • Musculoskeletal injuries: Facilitates recovery by diminishing pain and swelling after trauma.
  • Ankylosing spondylitis: Alleviates spinal pain and stiffness.

How It Works

  • Ketoprofen exerts its anti‑inflammatory and analgesic actions by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This blockade reduces the conversion of arachidonic acid to prostaglandins and thromboxanes, mediators that promote pain, fever and inflammation. By lowering prostaglandin synthesis at sites of tissue injury, ketoprofen diminishes peripheral sensitisation and provides systemic relief.

Side Effects

Ketoprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensation of light‑headedness.
  • Skin rash: mild erythema or pruritus.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding: potentially life‑threatening.
  • Renal impairment: acute kidney injury or worsening chronic kidney disease.
  • Hepatotoxicity: elevated liver enzymes or hepatitis.
  • Severe hypersensitivity: anaphylaxis, Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

When prescribing ketoprofen, clinicians should consider several safety precautions to minimise risk.

  • Renal function: assess baseline kidney function and monitor during therapy.
  • Gastrointestinal risk: avoid in patients with a history of ulcers or bleeding unless gastro‑protective agents are used.
  • Cardiovascular disease: use cautiously in patients with hypertension or heart failure.
  • Concomitant anticoagulants: monitor for increased bleeding tendency.
  • Pregnancy and lactation: evaluate risk‑benefit; avoid unless clearly needed.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Ketoprofen can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened risk of ulceration and bleeding.
  • Lithium: may raise serum lithium levels.
  • Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics: may diminish renal perfusion, monitor kidney function.
  • ACE inhibitors or ARBs: potential for reduced renal function.
  • Selective serotonin reuptake inhibitors (SSRIs): increased bleeding risk.
  • Blood pressure medications: possible attenuation of antihypertensive effect.

Frequently Asked Questions

Ketonal Forte contains ketoprofen, an NSAID that is used to relieve moderate to severe pain, reduce inflammation, and manage symptoms of arthritis and other musculoskeletal disorders. It is commonly prescribed for conditions such as osteoarthritis, rheumatoid arthritis, acute injuries, and postoperative pain where inflammation contributes to discomfort.

Ketoprofen works by inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for converting arachidonic acid into prostaglandins. Prostaglandins are chemical mediators that promote pain, fever, and inflammation. By lowering prostaglandin production, ketoprofen diminishes the inflammatory response and provides analgesic relief.

The appropriate dose of Ketonal Forte is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of symptoms, renal and hepatic function, and any concomitant medications. Dosage regimens can vary widely, so patients should follow the specific instructions provided by their prescriber.

Ketoprofen is generally classified as a drug to be used with caution during pregnancy, especially in the third trimester, because of potential risks to the fetus and complications during labor. It is also excreted in breast milk, so breastfeeding mothers should discuss alternatives with their healthcare provider before using Ketonal Forte.

To order Ketonal Forte, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including any cold‑chain requirements) and assist with import documentation.

Ketonal Forte (ketoprofen) and ibuprofen belong to the same NSAID class but differ in potency and pharmacokinetic profile. Ketoprofen often provides longer‑lasting analgesia and may be more effective for certain inflammatory conditions, while ibuprofen is widely used for mild to moderate pain with a well‑established safety record. Choice between them depends on clinical response, tolerability, and individual patient risk factors.

Ketonal Forte should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, direct sunlight and excessive heat. Do not store in bathrooms or near kitchen appliances that generate steam, and keep out of reach of children.

Ketonal Forte is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with meals may reduce gastrointestinal discomfort. Patients should swallow the tablet whole and avoid crushing or chewing unless specifically instructed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, hepatotoxicity, and hypersensitivity reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience black stools, vomiting blood, sudden loss of kidney function, jaundice, or any signs of a severe allergic reaction.

Ketonal Forte should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, and in patients taking anticoagulants without close monitoring. It is also contraindicated in the third trimester of pregnancy and in patients with significant renal or hepatic impairment unless benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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