Product image of Ketonal Forte (Ketoprofen) supplied by GNH India

Ketonal Forte

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal Forte (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal Forte, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It is employed to relieve mild to moderate pain and to reduce inflammation in conditions such as osteoarthritis, rheumatoid arthritis and other musculoskeletal disorders.

GNH India supplies Ketonal Forte as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution, ensuring product integrity and traceability.

Manufacturer / TM Owner

Lek Pharmaceuticals D.D. Ljubljana

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Indications & Clinical Uses

Ketoprofen is indicated for inflammatory and painful conditions affecting the musculoskeletal system.

  • Osteoarthritis: reduces joint pain and swelling, improving function.
  • Rheumatoid arthritis: alleviates chronic joint inflammation and discomfort.
  • Musculoskeletal pain: provides analgesic relief for strains, sprains and back pain.
  • Acute pain (e.g., dental or postoperative): controls short‑term pain after procedures.

How It Works

  • Ketoprofen exerts its anti‑inflammatory and analgesic actions by reversibly inhibiting cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitisation of nociceptors and decreases vascular permeability, thereby lowering pain, fever and inflammation at the site of tissue injury. This effect is dose‑dependent and contributes to the drug’s rapid onset of pain relief.

Side Effects

Ketoprofen may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia.
  • Nausea or vomiting.
  • Headache.
  • Dizziness.
  • Mild skin rash.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Severe liver injury.
  • Renal impairment or failure.
  • Hypersensitivity reactions such as Stevens‑Johnson syndrome.
  • Cardiovascular events including myocardial infarction.
  • Blood dyscrasias such as agranulocytosis.

Precautions & Warnings

When prescribing or dispensing Ketonal Forte, several safety considerations should be observed.

  • Assess renal function: evaluate kidney status before initiating therapy, especially in elderly patients.
  • Monitor gastrointestinal risk: avoid use in patients with active ulcers or a history of GI bleeding.
  • Evaluate cardiovascular history: use cautiously in individuals with coronary artery disease or hypertension.
  • Check for hypersensitivity: discontinue if rash, swelling or anaphylaxis occurs.
  • Avoid concomitant NSAIDs: limit combined use to reduce risk of adverse events.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoprofen can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • ACE inhibitors or ARBs: may impair renal function when combined.
  • Lithium: ketoprofen can raise lithium serum concentrations.

Moderate Interactions (Monitor Closely)

  • SSRIs: additive risk of gastrointestinal bleeding.
  • Diuretics: possible reduction in antihypertensive effect.
  • Methotrexate: may decrease its clearance, requiring monitoring.

Frequently Asked Questions

Ketonal Forte contains ketoprofen, an NSAID that is used to relieve mild to moderate pain and to reduce inflammation. It is commonly prescribed for conditions such as osteoarthritis, rheumatoid arthritis, musculoskeletal injuries, and short‑term acute pain after dental work or surgery.

Ketoprofen works by reversibly inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2. This inhibition blocks the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. By lowering prostaglandin levels, ketoprofen reduces tissue inflammation and the perception of pain.

The appropriate dose of Ketonal Forte is determined by the prescribing healthcare professional based on the individual’s condition, age, renal and hepatic function, and other medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of ketoprofen in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To order Ketonal Forte, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials. The sales team then replies with pricing, availability, shipping details and any required import documentation.

Both ketoprofen and ibuprofen belong to the NSAID class and share similar mechanisms of COX inhibition. Ketoprofen generally has a slightly longer half‑life and may provide more potent anti‑inflammatory effects, while ibuprofen is often preferred for its broader over‑the‑counter availability. Choice depends on clinical response, safety profile and physician preference.

Ketonal Forte tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Keep the product away from moisture, direct sunlight and heat sources. Do not store in the bathroom or near a kitchen sink to maintain tablet integrity.

Ketonal Forte is taken orally with a full glass of water. It may be taken with or without food; however, taking it with food can reduce gastrointestinal irritation. Swallow the tablet whole; do not crush or chew unless specifically instructed by a healthcare professional.

Serious risks include gastrointestinal ulceration or bleeding, severe liver injury, acute renal failure, cardiovascular events such as heart attack or stroke, and rare hypersensitivity reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice black stools, severe abdominal pain, jaundice, sudden swelling, or skin blistering.

Ketonal Forte should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment. It is also contraindicated in patients taking certain anticoagulants without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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