Product image of Ketonal Intensive (Ketoprofen Lysine) supplied by GNH India

Ketonal Intensive

Active Ingredient:
Ketoprofen Lysine
Origin:
EU

Ketonal Intensive (Ketoprofen Lysine)

Ketoprofen Lysine, the active ingredient in Ketonal Intensive, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for systemic use. It is employed to relieve mild to moderate pain and to reduce inflammation in conditions such as musculoskeletal disorders, rheumatoid arthritis, osteoarthritis, and dental pain.

GNH India supplies Ketonal Intensive as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution across multiple regulatory jurisdictions.

Manufacturer / TM Owner

Sandoz Pharmaceuticals D.D.

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Indications & Clinical Uses

  • Ketoprofen Lysine is indicated for several painful and inflammatory conditions affecting the musculoskeletal and dental systems.
  • Mild to moderate pain: provides analgesic relief for temporary discomfort such as headaches or minor injuries.
  • Musculoskeletal pain: reduces inflammation and pain associated with strains, sprains, and backache.
  • Rheumatoid arthritis: helps control joint inflammation and stiffness in chronic autoimmune disease.
  • Osteoarthritis: alleviates pain and improves joint function in degenerative joint disease.
  • Dental pain: diminishes postoperative or inflammatory pain following dental procedures.

How It Works

  • Ketoprofen Lysine exerts its anti‑inflammatory and analgesic effects by reversibly inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition blocks the conversion of arachidonic acid to prostaglandins, thereby decreasing prostaglandin synthesis at sites of inflammation. The reduced prostaglandin levels lead to diminished peripheral sensitization, lower pain perception, and attenuation of the inflammatory response.

Side Effects

Ketoprofen Lysine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness: transient vertigo or light‑headedness.

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding: potentially life‑threatening hemorrhage.
  • Hepatic injury: elevated liver enzymes or hepatitis.
  • Severe skin reactions: Stevens‑Johnson syndrome, toxic epidermal necrolysis, or anaphylaxis.

Precautions & Warnings

When prescribing Ketoprofen Lysine, clinicians should consider several safety precautions to minimise risk.

  • Assess renal function: evaluate kidney health before initiating therapy, especially in elderly patients.
  • Monitor hepatic status: check liver enzymes periodically in patients with pre‑existing liver disease.
  • Evaluate cardiovascular risk: use cautiously in individuals with history of heart disease or hypertension.
  • Review gastrointestinal history: avoid in patients with active ulcers or prior gastrointestinal bleeding.
  • Avoid concurrent NSAIDs: do not combine with other non‑steroidal anti‑inflammatory drugs to reduce additive toxicity.
  • Store at ambient temperature: keep below 25 °C in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Ketoprofen Lysine can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Selective COX‑2 inhibitors: additive gastrointestinal toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function when combined.
  • Diuretics: heightened risk of renal impairment and electrolyte imbalance.
  • Lithium: NSAIDs can raise lithium serum levels, risking toxicity.

Frequently Asked Questions

Ketonal Intensive, containing ketoprofen lysine, is prescribed for mild to moderate pain, musculoskeletal discomfort, rheumatoid arthritis, osteoarthritis, and dental pain. It helps reduce inflammation and provides analgesic relief in these recognized therapeutic areas.

Ketoprofen lysine works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes. This blocks prostaglandin production, which lowers inflammation and peripheral sensitisation, resulting in reduced pain perception.

The appropriate dose of Ketonal Intensive is determined by the prescribing clinician based on the patient’s condition, severity of symptoms, age, renal and hepatic function, and any concomitant medications. No fixed regimen is provided here.

Safety data for ketoprofen lysine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To order Ketonal Intensive, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketonal Intensive (ketoprofen lysine) and ibuprofen belong to the same NSAID class but differ in potency and pharmacokinetics. Ketoprofen often provides stronger analgesia at lower doses, while ibuprofen is widely used for milder pain. Both share similar gastrointestinal and cardiovascular risk profiles, so choice depends on clinical judgement and patient tolerance.

Ketonal Intensive should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original blister pack, protect them from moisture, heat and direct sunlight to maintain stability.

Ketonal Intensive is taken orally as a tablet with a full glass of water. It may be taken with or without food, although taking it with meals can reduce the likelihood of gastrointestinal discomfort.

Serious risks include gastrointestinal ulceration or bleeding, severe liver injury, acute kidney impairment, cardiovascular events such as myocardial infarction or stroke, and rare but life‑threatening skin reactions like Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience signs of these conditions.

Ketonal Intensive should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe renal or hepatic impairment, uncontrolled hypertension, and in patients who have had recent coronary artery bypass surgery or other major cardiovascular events.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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