Product image of Ketonal Prolong (Ketoprofen) supplied by GNH India

Ketonal Prolong

Active Ingredient:
Ketoprofen
Origin:
EU

Ketonal Prolong (Ketoprofen)

Ketoprofen, the active ingredient in Ketonal Prolong, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as an oral formulation for oral use. It is employed to relieve mild to moderate pain and to reduce inflammation in conditions such as osteoarthritis and rheumatoid arthritis. It is marketed across the European Union and is recognized for its consistent therapeutic profile.

GNH India supplies Ketonal Prolong as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution.

Manufacturer / TM Owner

Sandoz S.R.O.

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Indications & Clinical Uses

  • Ketoprofen is used to manage pain and inflammation associated with musculoskeletal and rheumatic disorders.
  • Mild to moderate pain: provides analgesic relief for acute or chronic pain conditions such as headache, musculoskeletal strain, or postoperative discomfort.
  • Osteoarthritis: reduces joint pain, stiffness and inflammation, helping improve functional mobility and quality of life in affected joints.
  • Rheumatoid arthritis: alleviates inflammatory symptoms, joint swelling and tenderness, contributing to disease management alongside disease‑modifying therapies.
  • Postoperative pain: assists in controlling pain after surgical procedures, facilitating early mobilization and recovery.
  • Dental pain: eases discomfort following dental extractions, periodontal procedures or other oral surgeries.

How It Works

  • Ketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The reduction in prostaglandin synthesis diminishes peripheral sensitisation of nociceptors, leading to decreased pain perception and attenuation of inflammatory responses in affected tissues.

Side Effects

Ketoprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Nausea or upset stomach
  • Dyspepsia or heartburn
  • Headache
  • Dizziness

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Renal impairment or reduced kidney function

Precautions & Warnings

  • Before initiating therapy with Ketoprofen, consider the following safety measures.
  • Assess gastrointestinal risk: evaluate history of ulcers, bleeding disorders or concurrent NSAID use.
  • Evaluate renal function: monitor creatinine and adjust use in patients with impaired kidneys.
  • Monitor cardiovascular status: use cautiously in patients with heart disease or high thrombotic risk.
  • Avoid use in third‑trimester pregnancy: NSAIDs may affect fetal circulation.
  • Use the lowest effective dose for the shortest duration needed.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Ketoprofen can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): elevated risk of bleeding.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in renal clearance.
  • Corticosteroids: additive risk of gastrointestinal ulceration.

Frequently Asked Questions

Ketonal Prolong contains ketoprofen, an NSAID that is prescribed to relieve mild to moderate pain and to reduce inflammation in disorders such as osteoarthritis, rheumatoid arthritis, postoperative pain, and dental pain. It is chosen when a non‑opioid analgesic with anti‑inflammatory properties is required.

Ketoprofen blocks the activity of both COX‑1 and COX‑2 enzymes, which are essential for producing prostaglandins that sensitize nerve endings and promote inflammation. By lowering prostaglandin levels, ketoprofen reduces peripheral nerve sensitisation, thereby decreasing pain signals and diminishing swelling and redness at the site of injury.

The appropriate dose of Ketonal Prolong is determined by the prescribing clinician based on the patient’s age, weight, medical condition, and response to therapy. Healthcare professionals tailor the regimen to achieve effective pain control while minimising potential adverse effects, and patients should follow the specific instructions provided on the prescription label.

Ketoprofen, like other NSAIDs, is generally avoided in the third trimester of pregnancy because it may affect fetal circulation and prolong labor. Safety during earlier stages of pregnancy and while breastfeeding has not been definitively established, so clinicians usually weigh the benefits against potential risks before prescribing it to pregnant or lactating women.

To request Ketonal Prolong, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Ketonal Prolong (ketoprofen) offers a balanced profile of analgesic and anti‑inflammatory activity, similar to ibuprofen and naproxen, but it may provide stronger pain relief in some musculoskeletal conditions. Its non‑selective COX inhibition can lead to a comparable gastrointestinal risk, so clinicians consider patient history and co‑medications when choosing between ketoprofen and other NSAIDs.

Ketonal Prolong should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Ketonal Prolong is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with meals may reduce the likelihood of gastrointestinal discomfort. Patients should swallow the tablet whole and not split, crush, or chew it unless directed otherwise by a healthcare professional.

The most serious risks include gastrointestinal ulceration or bleeding, severe skin reactions such as Stevens‑Johnson syndrome, and renal impairment that can lead to reduced kidney function. Patients should be monitored for signs of abdominal pain, blood in stool, rash, or sudden changes in urine output, and they should seek medical attention promptly if these occur.

Ketonal Prolong should be avoided in individuals with a known hypersensitivity to ketoprofen or other NSAIDs, those with active gastrointestinal ulcers or bleeding, severe renal or hepatic impairment, and patients in the third trimester of pregnancy. Additionally, patients taking anticoagulants, other NSAIDs, or SSRIs should discuss alternative therapies with their prescriber.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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