Product image of Ketopine (Ketoconazole) supplied by GNH India

Ketopine

Active Ingredient:
Ketoconazole
Origin:
EU

Ketopine (Ketoconazole)

Ketoconazole, the active ingredient in Ketopine, is a azole antifungal presented as a topical formulation for topical use. It treats common superficial fungal infections of the skin and scalp in adults and children.
GNH India supplies Ketopine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pinewood Laboratories Limited

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Indications & Clinical Uses

  • Ketopine, an azole antifungal, acts on dermatophyte and yeast infections of the skin and scalp.
  • Tinea corporis: reduces fungal growth and clears body ringworm lesions.
  • Tinea cruris: alleviates itching and scaling in the groin area.
  • Tinea pedis: improves foot skin condition by eliminating athlete's foot fungi.
  • Seborrheic dermatitis: controls Malassezia overgrowth and eases scalp flaking.

How It Works

  • Ketoconazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. Disruption of ergosterol production compromises the integrity of the fungal cell membrane, leading to impaired growth and cell death of susceptible dermatophytes and yeasts.

Side Effects

Ketopine may cause local skin reactions.

Common Side Effects

  • Burning sensation at the application site
  • Itching or pruritus
  • Redness or erythema
  • Dryness or peeling skin
  • Irritation or stinging
  • Scaling or flaking

Serious or Rare Side Effects

  • Allergic contact dermatitis
  • Severe skin rash or urticaria
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Photosensitivity reactions
  • Hepatic toxicity (systemic absorption rare)
  • Secondary bacterial infection of the treated area

Precautions & Warnings

  • Before using Ketopine, consider the following safety measures.
  • Apply to intact skin: avoid broken skin, mucous membranes, or open wounds.
  • Avoid ocular contact: rinse eyes thoroughly if exposure occurs.
  • Limit duration of use: follow prescriber instructions and discontinue if irritation persists.
  • Do not combine with other topical antifungals unless directed by a healthcare professional.
  • Pregnancy and lactation: safety not established; consult a healthcare provider before use.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Ketopine may interact with other medications or agents.

Major Interactions (Avoid)

  • Oral ketoconazole: concurrent use may increase systemic exposure.
  • Rifampin: may reduce antifungal efficacy.
  • Topical corticosteroids: may increase local irritation.

Moderate Interactions (Monitor Closely)

  • Other topical antifungals: may cause additive skin irritation.
  • Alcohol‑based skin products: may enhance absorption and irritation.
  • Phototoxic agents: increase risk of photosensitivity reactions.

Frequently Asked Questions

Ketopine is a topical azole antifungal indicated for the treatment of superficial fungal skin infections such as tinea corporis (body ringworm), tinea cruris (jock itch), tinea pedis (athlete's foot), and seborrheic dermatitis caused by Malassezia species.

Ketoconazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for ergosterol synthesis. Without ergosterol, the fungal cell membrane becomes unstable, inhibiting growth and leading to cell death of the targeted dermatophytes and yeasts.

The dosage and frequency of Ketopine are determined by the prescribing healthcare professional based on the specific infection, severity, patient age, and treatment response. Patients should follow the prescriber’s instructions and the product label.

Safety data for topical ketoconazole in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Ketopine.

To order Ketopine, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ketopine’s active ingredient, ketoconazole, belongs to the azole class and offers broad‑spectrum activity against dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, azoles may have a slightly slower onset but are effective for a wide range of skin infections and are available in convenient topical forms.

Ketopine should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Apply a thin layer of Ketopine to the affected skin area once or twice daily, as directed by the prescriber. Gently rub the cream into clean, dry skin and wash your hands after application, avoiding contact with eyes and mucous membranes.

Serious adverse reactions, although rare, can include severe allergic skin reactions such as Stevens‑Johnson syndrome, toxic epidermal necrolysis, or widespread dermatitis. If any signs of a severe rash, blistering, or systemic symptoms appear, discontinue use and seek immediate medical attention.

Ketopine should not be used on broken skin, mucous membranes, or in patients with a known hypersensitivity to ketoconazole or any other component of the formulation. Individuals with severe liver disease should also avoid topical ketoconazole unless specifically advised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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