Product image of Ketoplus (Ketoprofen) supplied by GNH India

Ketoplus

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoplus (Ketoprofen)

Ketoprofen, the active ingredient in Ketoplus, is a nonsteroidal anti-inflammatory drug presented as an oral tablet for oral use. It is employed to relieve pain, reduce inflammation and lower fever in adults with musculoskeletal conditions.

GNH India supplies Ketoplus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

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Indications & Clinical Uses

Ketoprofen acts on inflammatory pathways and is indicated for several painful and inflammatory conditions.

  • Pain: Provides analgesic relief in acute and chronic pain states such as postoperative pain or dental pain.
  • Inflammation: Reduces swelling and redness in soft‑tissue injuries and postoperative sites.
  • Arthritis: Alleviates joint pain and stiffness associated with osteoarthritis and rheumatoid arthritis.
  • Musculoskeletal disorders: Improves function and comfort in conditions like tendinitis, bursitis and low‑back strain.

How It Works

  • Ketoprofen inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, blocking the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes inflammation, pain signalling and fever generation at the site of tissue injury.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort, including dyspepsia or nausea.
  • Headache or dizziness.
  • Mild skin rash or itching.
  • Elevated blood pressure.
  • Fluid retention or mild edema.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Severe renal impairment or sudden loss of kidney function.
  • Life‑threatening hypersensitivity reactions such as Stevens‑Johnson syndrome.
  • Anaphylactic shock.
  • Hepatotoxicity with jaundice.
  • Cardiovascular events such as myocardial infarction or stroke.

Precautions & Warnings

Before initiating ketoprofen therapy, consider the following safety measures.

  • Assess gastrointestinal risk: avoid in patients with active ulcers or a history of GI bleeding.
  • Monitor renal function: adjust use in those with impaired kidney function.
  • Use lowest effective dose: limit duration to the shortest period needed for symptom control.
  • Avoid in known hypersensitivity to ketoprofen or other NSAIDs.
  • Caution in cardiovascular disease: evaluate risk of thrombotic events.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Ketoprofen can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened risk of ulceration and bleeding.
  • Lithium: possible increase in lithium serum levels.
  • Methotrexate: reduced clearance leading to toxicity.

Moderate Interactions (Monitor Closely):\n- Antihypertensives (e.g., ACE inhibitors, ARBs): may diminish blood‑pressure‑lowering effect.

  • Diuretics: potential for reduced renal perfusion.
  • Digoxin: possible increase in serum concentration.
  • Cyclosporine: enhanced nephrotoxicity risk.
  • SSRIs or SNRIs: modest increase in bleeding tendency.

Frequently Asked Questions

Ketoplus contains ketoprofen, an NSAID that is commonly prescribed to manage moderate pain, reduce inflammation, and treat arthritis and other musculoskeletal disorders. It is used when physicians need an oral analgesic and anti‑inflammatory option for conditions such as osteoarthritis, rheumatoid arthritis, postoperative pain, and soft‑tissue injuries.

Ketoprofen works by blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin levels, the drug diminishes the inflammatory response, reduces pain signalling, and helps lower fever, providing symptomatic relief in affected tissues.

The appropriate dose of Ketoplus is determined by the prescribing healthcare professional based on the individual’s medical condition, age, weight, and response to therapy. Patients should follow the prescriber’s instructions and never adjust the dose without medical guidance.

Safety of ketoprofen in pregnancy and lactation has not been definitively established. It is generally avoided, especially in the third trimester, because of potential risks to the fetus and newborn. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative treatments with their healthcare provider.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoplus (ketoprofen) offers analgesic and anti‑inflammatory potency comparable to ibuprofen and naproxen, but it may have a slightly higher risk of gastrointestinal irritation. Its relatively short half‑life allows flexible dosing, while some clinicians prefer it for conditions where a rapid onset of pain relief is desired.

Ketoplus should be stored at room temperature, preferably below 25 °C. Keep the tablets in the original packaging to protect them from moisture and light, and store them out of reach of children.

Ketoplus is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with meals may reduce the likelihood of stomach upset. The exact administration schedule should follow the prescriber’s directions.

The most serious risks include gastrointestinal bleeding or ulceration, severe renal impairment, life‑threatening allergic reactions such as Stevens‑Johnson syndrome, and increased cardiovascular events like heart attack or stroke. Patients should seek immediate medical attention if they notice signs of bleeding, severe rash, or sudden kidney problems.

Ketoplus should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, or significant renal or hepatic impairment. It is also contraindicated in patients taking certain anticoagulants or other NSAIDs without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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