Product image of Ketoprofen Ennogen Pharma (Ketoprofen) supplied by GNH India

Ketoprofen Ennogen Pharma

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoprofen Ennogen Pharma (Ketoprofen)

Ketoprofen, the active ingredient in Ketoprofen Ennogen Pharma, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is employed to relieve mild to moderate pain and to reduce inflammation in conditions such as arthritis, musculoskeletal disorders, and dysmenorrhea.

GNH India supplies Ketoprofen Ennogen Pharma as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ennogen Pharma Limited

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Indications & Clinical Uses

Ketoprofen is indicated for several inflammatory and pain‑related conditions, acting primarily through cyclo‑oxygenase inhibition.

  • Mild to moderate pain: provides analgesic relief for acute or chronic pain conditions.
  • Rheumatoid arthritis: reduces joint inflammation and improves mobility.
  • Osteoarthritis: alleviates joint pain and stiffness associated with degenerative cartilage loss.
  • Musculoskeletal pain: diminishes soreness and swelling in muscles, tendons, and ligaments.
  • Dysmenorrhea: eases menstrual cramps by decreasing uterine prostaglandin production.

How It Works

  • Ketoprofen exerts its therapeutic effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis reduces inflammation, pain signaling, and fever responses at the site of tissue injury.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal upset: nausea, dyspepsia, or abdominal discomfort.
  • Headache: mild to moderate intensity.
  • Dizziness: transient sensations of light‑headedness.
  • Skin rash: mild erythema or pruritus.

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding: potentially life‑threatening hemorrhage.
  • Renal impairment: reduced kidney function or acute failure.
  • Hepatic dysfunction: elevated liver enzymes or hepatitis.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Anaphylaxis: rapid onset of airway swelling, hypotension, and shock.
  • Cardiovascular events: increased risk of thrombosis or myocardial infarction.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Assess renal function: adjust use in patients with existing kidney disease.
  • Monitor gastrointestinal risk: avoid in individuals with a history of ulcer or bleeding.
  • Evaluate cardiovascular status: use cautiously in patients with heart disease or hypertension.
  • Review concomitant medications: avoid combining with other NSAIDs or anticoagulants without supervision.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Ketoprofen can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): heightened risk of serious bleeding.
  • Selective COX‑2 inhibitors: additive renal toxicity and gastrointestinal injury.
  • Lithium: increased serum lithium concentrations leading to toxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: potential reduction in renal function.
  • Diuretics: enhanced risk of dehydration and renal impairment.
  • Methotrexate: decreased clearance may raise methotrexate toxicity.

Frequently Asked Questions

Ketoprofen Ennogen Pharma is an oral NSAID indicated for the relief of mild to moderate pain and the reduction of inflammation in conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, and dysmenorrhea. It works by decreasing prostaglandin production, which helps alleviate pain and swelling.

Ketoprofen inhibits both COX‑1 and COX‑2 enzymes, blocking the conversion of arachidonic acid to prostaglandins. This reduction in prostaglandin synthesis leads to decreased inflammation, pain signaling, and fever, providing symptomatic relief in a variety of painful and inflammatory disorders.

The appropriate dose of ketoprofen is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and renal or hepatic function. Dosage regimens may vary, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

Safety data for ketoprofen in pregnancy are limited, and it is generally avoided, especially in the third trimester, due to potential fetal risks. While small amounts may be excreted in breast milk, nursing mothers should consult their physician before using ketoprofen.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Both ketoprofen and ibuprofen are non‑selective NSAIDs that reduce pain and inflammation. Ketoprofen often has a longer half‑life, allowing less frequent dosing, and may provide stronger analgesia in some patients. However, both share similar gastrointestinal and cardiovascular risk profiles, so choice depends on clinical response and tolerability.

Ketoprofen should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments.

Ketoprofen is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with meals may reduce gastrointestinal discomfort. Patients should swallow tablets whole and not crush or chew them unless directed by a healthcare professional.

Serious risks include gastrointestinal ulceration or bleeding, renal impairment, hepatic dysfunction, severe skin reactions such as Stevens‑Johnson syndrome, anaphylaxis, and increased cardiovascular events like myocardial infarction or stroke. Patients should be monitored for these events, especially if they have pre‑existing risk factors.

Ketoprofen is contraindicated in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe heart failure, and those who have had a recent coronary artery bypass graft. Caution is also advised for patients with impaired renal or hepatic function.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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