Ketoprofen Dompé (Ketoprofen Lysine)

Ketoprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

• Mild to moderate pain: provides analgesic relief for acute and chronic pain states.
• Osteoarthritis: reduces joint pain and improves mobility.
• Rheumatoid arthritis: alleviates inflammatory joint symptoms.
• Musculoskeletal pain: eases discomfort from strains, sprains and overuse.
• Dysmenorrhea: relieves menstrual cramps and associated pelvic pain.

• Ketoprofen lysine reversibly inhibits both COX‑1 and COX‑2 enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis leads to diminished inflammation, pain signalling, and fever generation, providing analgesic and anti‑inflammatory effects throughout the body.

Ketoprofen may cause a range of adverse reactions, from mild to serious.

Common Side Effects

• Gastrointestinal upset: nausea, dyspepsia or abdominal discomfort.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Skin rash or pruritus.

Serious or Rare Side Effects

• Gastrointestinal bleeding or ulcer perforation.
• Acute renal impairment or failure.
• Severe hypersensitivity reactions, including anaphylaxis.
• Hepatic dysfunction with elevated transaminases.
• Life‑threatening skin reactions such as Stevens‑Johnson syndrome.

Before initiating therapy, consider the following safety measures.

• Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
• Monitor renal function: check serum creatinine in patients with kidney disease.
• Avoid in known hypersensitivity: discontinue immediately if allergic signs appear.
• Use the lowest effective dose: limit duration to reduce adverse events.
• Store at ambient temperature: keep below 25 °C in the original pack, protect from moisture.

Ketoprofen can interact with several drug classes; some combinations should be avoided while others require close monitoring.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
• High‑dose aspirin: heightened cardiovascular and renal risk.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may diminish renal function, especially in dehydrated patients.
• Diuretics: potential for reduced renal perfusion.
• Lithium: ketoprofen can raise lithium serum concentrations, requiring level checks.