Ketoprofen Dompé (Ketoprofen Lysine)

Ketoprofen Dompé belongs to the NSAID class and is indicated for inflammatory and painful musculoskeletal disorders.

• Mild to moderate pain: provides analgesic relief for acute or chronic pain conditions.
• Rheumatoid arthritis: reduces joint inflammation and improves functional ability.
• Osteoarthritis: alleviates pain and stiffness associated with degenerative joint disease.
• Musculoskeletal pain: eases discomfort from strains, sprains and overuse injuries.

• Ketoprofen Lysine reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis leads to diminished inflammation, pain signaling, and fever responses at sites of tissue injury.

Ketoprofen Dompé may cause a range of adverse reactions.

Common Side Effects

• Gastro‑intestinal discomfort: nausea, dyspepsia or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo: transient sensations of light‑headedness.
• Skin rash: mild erythema or pruritus.

Serious or Rare Side Effects

• Gastro‑intestinal ulcer or bleeding: potentially life‑threatening hemorrhage.
• Renal impairment: acute kidney injury or reduced renal function.
• Hepatic dysfunction: elevated liver enzymes or hepatitis.
• Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Anaphylaxis: rapid onset of airway compromise and circulatory collapse.

Before initiating therapy, consider the following safety measures.

• Assess renal function: monitor creatinine in patients with existing kidney disease.
• Evaluate gastrointestinal risk: avoid in individuals with active ulcers or a history of serious GI bleeding.
• Review cardiovascular status: use cautiously in patients with heart failure or uncontrolled hypertension.
• Check concomitant medications: avoid combining with other NSAIDs, anticoagulants or corticosteroids without supervision.
• Store at ambient temperature: keep below 25 °C, retain in original packaging, and protect from moisture.

Ketoprofen Lysine can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

• Diuretics: may reduce renal perfusion and exacerbate kidney injury.
• ACE inhibitors or ARBs: potential for impaired renal function when combined.
• Lithium: NSAIDs can raise lithium serum concentrations, risking toxicity.