Product image of Ketoprofen Dompé (Ketoprofen Lysine) supplied by GNH India

Ketoprofen Dompé

Active Ingredient:
Ketoprofen Lysine
Origin:
EU

Ketoprofen Dompé (Ketoprofen Lysine)

Ketoprofen lysine, the active ingredient in Ketoprofen Dompé, is a nonsteroidal anti‑inflammatory drug presented as a tablet for oral use. It provides analgesic and anti‑inflammatory effects for adults with mild to moderate pain and inflammatory musculoskeletal conditions.

GNH India supplies Ketoprofen Dompé as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Dompé Farmaceutici S.P.A.

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Indications & Clinical Uses

Ketoprofen Dompé acts on inflammatory pathways to relieve pain and swelling in several musculoskeletal disorders.

  • Mild to moderate pain: reduces pain intensity and improves functional ability.
  • Osteoarthritis: alleviates joint discomfort and enhances mobility.
  • Rheumatoid arthritis: decreases inflammation and swelling in affected joints.

How It Works

  • Ketoprofen lysine reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which reduces the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels diminish inflammation, pain signaling, and fever responses in the body.

Side Effects

Ketoprofen Dompé may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness: transient episodes of light‑headedness.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Gastrointestinal ulcer or bleeding: potentially life‑threatening hemorrhage.
  • Severe hepatic injury: jaundice, elevated liver enzymes, or liver failure.
  • Anaphylactic reaction: hives, airway swelling, and respiratory distress.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Assess renal function: adjust use in patients with impaired kidneys.
  • Avoid in active peptic ulcer disease: increased risk of gastrointestinal bleeding.
  • Use caution with cardiovascular disease: NSAIDs may elevate cardiovascular risk.
  • Monitor liver enzymes: potential for hepatotoxicity with prolonged use.
  • Avoid concomitant anticoagulants: heightened bleeding tendency.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Ketoprofen Dompé can interact with several medication classes; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin, heparin): increased risk of serious bleeding.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): heightened hemorrhage risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: may reduce renal function when combined.
  • Diuretics: potential for renal impairment.
  • Lithium: NSAIDs can raise serum lithium concentrations.

Frequently Asked Questions

Ketoprofen Dompé is indicated for the relief of mild to moderate pain and for the management of inflammatory conditions such as osteoarthritis and rheumatoid arthritis. It helps reduce pain intensity, swelling, and stiffness in affected joints, improving overall functional ability.

Ketoprofen lysine works by reversibly inhibiting the cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes. This inhibition blocks the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever, thereby providing analgesic and anti‑inflammatory effects.

The appropriate dose of Ketoprofen Dompé is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of ketoprofen during pregnancy or lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Ketoprofen Dompé, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Ketoprofen is an NSAID similar to ibuprofen but generally offers a slightly higher potency for COX inhibition, which can translate into stronger analgesic and anti‑inflammatory effects at comparable doses. However, the safety profile, especially gastrointestinal risk, is comparable and must be weighed against therapeutic benefits.

Ketoprofen Dompé should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Ketoprofen Dompé is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce the likelihood of gastrointestinal discomfort. Follow the prescriber’s guidance on timing and frequency.

The most serious risks include gastrointestinal ulceration or bleeding, cardiovascular events such as heart attack or stroke, and renal impairment, especially in patients with pre‑existing kidney disease. Prompt medical attention is required if signs of serious bleeding, chest pain, or sudden loss of kidney function occur.

Ketoprofen Dompé should be avoided in individuals with known hypersensitivity to ketoprofen or other NSAIDs, active peptic ulcer disease, severe heart failure, uncontrolled hypertension, and those on anticoagulant therapy without close monitoring. Pregnant women in the third trimester and patients with significant renal or hepatic impairment should also refrain from use unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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