Product image of Ketoprofen Dompé (Ketoprofen Lysine) supplied by GNH India

Ketoprofen Dompé

Active Ingredient:
Ketoprofen Lysine
Origin:
EU

Ketoprofen Dompé (Ketoprofen Lysine)

Ketoprofen Lysine, the active ingredient in Ketoprofen Dompé, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is employed to relieve mild to moderate pain and to reduce inflammation in musculoskeletal conditions such as rheumatoid arthritis and osteoarthritis.

GNH India supplies Ketoprofen Dompé as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across global markets.

Manufacturer / TM Owner

Dompé Farmaceutici S.P.A.

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Indications & Clinical Uses

Ketoprofen Lysine is used to manage pain and inflammation associated with musculoskeletal and rheumatic disorders.

  • Mild to moderate pain: provides analgesic relief for acute pain such as dental or postoperative discomfort.
  • Inflammatory musculoskeletal conditions: reduces swelling and discomfort in tendonitis or bursitis.
  • Rheumatoid arthritis: helps control joint inflammation and pain in chronic rheumatoid disease.
  • Osteoarthritis: alleviates chronic joint pain and stiffness associated with osteoarthritis.

How It Works

  • Ketoprofen Lysine exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes inflammation, pain, and fever, providing its therapeutic anti‑inflammatory and analgesic actions.

Side Effects

Ketoprofen Lysine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Severe hypersensitivity reactions: anaphylaxis, Stevens‑Johnson syndrome.
  • Renal impairment: acute kidney injury or worsening of chronic kidney disease.

Precautions & Warnings

When prescribing Ketoprofen Lysine, clinicians should consider several safety precautions to minimize risk.

  • Assess gastrointestinal risk: avoid in patients with active ulcers or history of GI bleeding.
  • Monitor renal function: use cautiously in patients with impaired kidney function.
  • Evaluate cardiovascular status: consider risk in patients with hypertension or heart disease.
  • Review concomitant medications: avoid use with other NSAIDs or anticoagulants without supervision.
  • Pregnancy and lactation: safety not established; use only if benefits outweigh potential risks.
  • Store at ambient temperature: keep below 25°C in the original packaging, protect from moisture and light.

Avoid Interactions

Ketoprofen Lysine can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Other NSAIDs or aspirin: heightened gastrointestinal toxicity.
  • Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or diuretics: possible reduction in renal function.
  • Lithium: NSAIDs may raise lithium serum levels.
  • Corticosteroids: additive risk of GI ulceration.

Frequently Asked Questions

Ketoprofen Dompé contains ketoprofen lysine, an NSAID indicated for the relief of mild to moderate pain and for reducing inflammation in conditions such as rheumatoid arthritis, osteoarthritis, and other inflammatory musculoskeletal disorders.

Ketoprofen lysine works by non‑selectively inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which reduces the synthesis of prostaglandins—key mediators of inflammation, pain, and fever—thereby providing analgesic and anti‑inflammatory effects.

The appropriate dose of Ketoprofen Dompé is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of ketoprofen lysine in pregnancy and lactation has not been firmly established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Ketoprofen Dompé, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoprofen is an NSAID similar to ibuprofen and naproxen but is often considered more potent on a milligram‑per‑milligram basis. Like other NSAIDs, it shares a similar risk profile for gastrointestinal, renal and cardiovascular adverse effects, so choice of agent depends on individual patient factors and clinician judgment.

Ketoprofen Dompé should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability.

Ketoprofen Dompé is administered orally. The tablet or capsule should be swallowed whole with a full glass of water, preferably with food or milk to lessen potential gastrointestinal irritation, unless otherwise directed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, severe allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome, and renal impairment that may manifest as reduced urine output or worsening kidney function. Patients should seek immediate medical attention if they experience these symptoms.

Ketoprofen Dompé should be avoided in individuals with a known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulcer disease, severe renal or hepatic impairment, and in patients taking anticoagulants or other NSAIDs without medical supervision. Pregnant women in the third trimester should also refrain from use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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