Product image of Ketoprofen Sf (Ketoprofen) supplied by GNH India

Ketoprofen Sf

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoprofen Sf (Ketoprofen)

Ketoprofen, the active ingredient in Ketoprofen Sf, is a Nonsteroidal anti-inflammatory drug (NSAID) presented as an injection for intramuscular use. It treats mild to moderate pain and inflammatory conditions such as rheumatoid arthritis, osteoarthritis, and musculoskeletal injuries in adults. It is indicated for adults requiring rapid analgesia and anti‑inflammatory effect, and is administered by healthcare professionals in clinical settings.

GNH India supplies Ketoprofen Sf as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets.

Manufacturer / TM Owner

Sun-Farm Sp. Z.O.O.

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Indications & Clinical Uses

  • Ketoprofen acts as an NSAID to reduce inflammation and pain in musculoskeletal and joint disorders.
  • Rheumatoid arthritis: reduces joint pain, swelling and stiffness, improving functional ability.
  • Osteoarthritis: alleviates chronic joint discomfort and improves mobility.
  • Musculoskeletal pain and sprains: provides rapid analgesic and anti‑inflammatory relief.
  • Post‑operative pain: helps control moderate pain after surgical procedures.

How It Works

  • Ketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes inflammation, pain signaling, and fever, providing analgesic and anti‑inflammatory actions at the site of tissue injury. By limiting prostaglandin‑mediated vasodilation and leukocyte infiltration, ketoprofen also reduces edema and the sensitization of nociceptors.

Side Effects

Ketoprofen may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Nausea: mild stomach upset may occur.
  • Dyspepsia: indigestion or heartburn.
  • Headache: transient headache.
  • Injection site pain: local discomfort at the administration site.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Renal impairment: reduced kidney function.
  • Severe hypersensitivity reactions: rash, angioedema, anaphylaxis.

Precautions & Warnings

Before prescribing ketoprofen, clinicians should evaluate patient-specific risk factors and monitor therapy appropriately.

  • Assess renal function: evaluate baseline kidney function before initiating therapy.
  • Monitor gastrointestinal risk: consider ulcer prophylaxis in patients with history of GI bleeding.
  • Avoid in known hypersensitivity: do not use if patient has allergy to ketoprofen or other NSAIDs.
  • Use caution with anticoagulants: increased bleeding risk when combined with warfarin or similar agents.
  • Pregnancy and lactation: safety not established; avoid unless benefits outweigh risks.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Ketoprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Concurrent use with anticoagulants (e.g., warfarin): increased risk of serious bleeding.
  • Combination with other NSAIDs or COX‑2 inhibitors: additive gastrointestinal toxicity.
  • Use with selective serotonin reuptake inhibitors (SSRIs): heightened bleeding tendency.

Moderate Interactions (Monitor Closely)

  • Concomitant diuretics or ACE inhibitors: may reduce renal perfusion and function.
  • Lithium therapy: NSAIDs can raise lithium plasma levels, risking toxicity.
  • Methotrexate: reduced clearance may increase methotrexate toxicity.

Frequently Asked Questions

Ketoprofen Sf is prescribed for mild to moderate pain and for inflammatory conditions such as rheumatoid arthritis, osteoarthritis, musculoskeletal pain, sprains, and post‑operative discomfort. It is used in adult patients when a rapid, injectable anti‑inflammatory effect is required.

Ketoprofen works by non‑selectively blocking the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin levels, it reduces inflammation, pain signalling, fever, and the swelling associated with tissue injury.

The dose of Ketoprofen Sf is determined by the prescribing healthcare professional based on the patient’s clinical condition, severity of pain or inflammation, weight, renal and hepatic function, and any concomitant medications. No fixed regimen is provided here; the prescriber sets the appropriate dose.

Safety data for ketoprofen during pregnancy and lactation are limited, and the product is classified as having an unknown pregnancy category. It should be avoided unless the potential benefit justifies the potential risk to the fetus or infant, and only under medical supervision.

To order Ketoprofen Sf, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Ketoprofen is a non‑selective NSAID like ibuprofen but generally has a higher potency for COX inhibition, which can provide stronger analgesic and anti‑inflammatory effects at comparable doses. However, its risk profile for gastrointestinal and renal adverse events may also be higher, so clinicians weigh efficacy against safety for each patient.

Ketoprofen Sf should be stored at ambient temperature, below 25 °C. Keep the vials in their original packaging, protect them from moisture and direct light, and avoid freezing. Follow any additional handling instructions provided on the label.

Ketoprofen Sf is administered by a qualified healthcare professional as a single intramuscular injection. The injection site is typically the gluteal muscle, and the volume and concentration are determined by the prescriber. It should be given under aseptic conditions.

The most serious risks include gastrointestinal ulceration or bleeding, acute renal impairment, and severe hypersensitivity reactions such as anaphylaxis, Stevens‑Johnson syndrome, or toxic epidermal necrolysis. Patients should be monitored for signs of these events, especially if they have pre‑existing risk factors.

Ketoprofen Sf should not be used by patients with known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal ulcer or bleeding, severe renal or hepatic impairment, and those receiving anticoagulant therapy where bleeding risk is unacceptable. Caution is also advised in the elderly and in patients with cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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