Ketoprofen Sr Terapia (Ketoprofen)

Ketoprofen is an NSAID that reduces pain and inflammation in several musculoskeletal conditions.

• Mild to moderate pain: provides analgesic relief for acute and chronic pain.
• Rheumatoid arthritis: helps control joint inflammation and swelling.
• Osteoarthritis: reduces pain and improves joint function.
• Musculoskeletal pain: alleviates discomfort from strains, sprains, and overuse.
• Inflammation: diminishes localized swelling in various tissues.

• Ketoprofen reversibly inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, decreasing the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis leads to lower inflammation, pain signaling, and fever responses at the site of tissue injury.

Ketoprofen may cause a range of adverse reactions, from mild to serious.

Common Side Effects

• Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
• Headache: mild to moderate intensity.
• Dizziness or vertigo.
• Skin rash or mild itching.
• Elevated liver enzymes (asymptomatic).

Serious or Rare Side Effects

• Peptic ulcer disease or gastrointestinal bleeding.
• Severe hypersensitivity reactions, including Stevens‑Johnson syndrome.
• Renal impairment or acute kidney injury.
• Cardiovascular events such as myocardial infarction or stroke.
• Hepatotoxicity with jaundice.
• Blood dyscrasias like agranulocytosis.

Ketoprofen should be used with caution in specific clinical situations.

• Assess gastrointestinal risk: avoid in patients with a history of ulcers or bleeding.
• Monitor renal function: use carefully in those with existing kidney disease.
• Evaluate cardiovascular status: consider risk in patients with heart disease.
• Review concomitant medications: avoid combining with other NSAIDs or anticoagulants without supervision.
• Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture.

Ketoprofen can interact with several drug classes, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased bleeding risk.
• Other NSAIDs or COX‑2 inhibitors: heightened gastrointestinal toxicity.
• Selective serotonin reuptake inhibitors (SSRIs): elevated bleeding potential.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: possible reduction in renal function.
• Diuretics: may enhance nephrotoxic effects.
• Lithium: NSAIDs can raise lithium serum levels.