Product image of Ketoprofen Vitabalans (Ketoprofen) supplied by GNH India

Ketoprofen Vitabalans

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoprofen Vitabalans (Ketoprofen)

Ketoprofen, the active ingredient in Ketoprofen Vitabalans, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral dosage form for oral use. It is used to relieve pain, reduce inflammation, and manage arthritis symptoms in adult patients. It is marketed throughout the European Union and is available in generic form for prescription use.

GNH India supplies Ketoprofen Vitabalans as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution.

Manufacturer / TM Owner

Vitabalans Oy

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Indications & Clinical Uses

Ketoprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

  • Pain: Provides analgesic relief for mild to moderate musculoskeletal pain.
  • Inflammation: Decreases inflammatory response in acute inflammatory conditions such as sprains.
  • Arthritis: Improves joint function and reduces swelling in osteoarthritis and rheumatoid arthritis.
  • Post‑operative pain: Assists in managing pain following surgical procedures.
  • Dysmenorrhea: Relieves menstrual cramps associated with primary dysmenorrhea.

How It Works

  • Ketoprofen exerts its effect by reversibly inhibiting the cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which catalyze the conversion of arachidonic acid to prostaglandins. By reducing prostaglandin synthesis, it diminishes peripheral sensitization of nociceptors and the inflammatory cascade, leading to analgesic, antipyretic, and anti‑inflammatory outcomes. The inhibition is dose‑dependent and temporary, allowing normal prostaglandin production to resume after the drug is cleared, which helps limit long‑term suppression of protective gastric prostaglandins.

Side Effects

Ketoprofen may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate headache episodes.
  • Dizziness: transient sensation of light‑headedness.
  • Skin rash: mild erythema or pruritus.

Serious or Rare Side Effects

  • Peptic ulcer disease: gastrointestinal bleeding or perforation.
  • Renal impairment: acute kidney injury or reduced renal function.
  • Cardiovascular events: increased risk of myocardial infarction or stroke.
  • Severe hypersensitivity: anaphylaxis or Stevens‑Johnson syndrome.

Precautions & Warnings

When using Ketoprofen, several precautions should be observed to minimize risk.

  • Assess renal function: evaluate kidney health before initiating therapy.
  • Monitor gastrointestinal risk: avoid use in patients with a history of ulcers or bleeding.
  • Use lowest effective dose: prescribe the minimal dose needed for symptom control.
  • Caution in cardiovascular disease: consider increased risk of thrombotic events.
  • Avoid concurrent NSAIDs: do not combine with other non‑steroidal anti‑inflammatory drugs.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Ketoprofen can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Anticoagulants: increased bleeding risk when combined with warfarin or direct oral anticoagulants.
  • ACE inhibitors/ARBs: may reduce renal protective effects and worsen kidney function.
  • Lithium: can raise lithium serum levels, risking toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance nephrotoxic potential.
  • Corticosteroids: additive gastrointestinal ulcer risk.
  • Methotrexate: possible increased toxicity at high doses.

Frequently Asked Questions

Ketoprofen Vitabalans is used to relieve mild to moderate pain, reduce inflammation, and manage symptoms of arthritis such as swelling and joint stiffness. It is commonly prescribed for musculoskeletal pain, postoperative discomfort, and conditions where inflammation plays a key role.

Ketoprofen works by reversibly inhibiting the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin levels, it reduces the sensitisation of pain receptors and the inflammatory cascade, providing analgesic and anti‑inflammatory effects.

The appropriate dose of ketoprofen is determined by the prescribing healthcare professional based on the individual’s condition, age, weight, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety of ketoprofen in pregnancy and lactation has not been definitively established. It is generally advised to avoid NSAIDs, including ketoprofen, during the third trimester and to discuss potential risks with a healthcare provider before use in pregnancy or while breastfeeding.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Ketoprofen and ibuprofen belong to the same NSAID class and share a similar mechanism of COX inhibition. Ketoprofen is often considered more potent on a milligram‑per‑milligram basis, but both carry comparable risks of gastrointestinal, renal and cardiovascular side effects. Choice depends on clinical response, dosing convenience and physician preference.

Ketoprofen Vitabalans should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original container, protect it from moisture and direct sunlight, and ensure that it is out of reach of children.

Ketoprofen Vitabalans is administered orally. The tablet (or capsule) should be swallowed whole with a full glass of water, preferably with food or milk to minimise gastrointestinal irritation, unless otherwise directed by a healthcare professional.

Serious risks include gastrointestinal bleeding or ulceration, severe kidney injury, cardiovascular events such as heart attack or stroke, and life‑threatening allergic reactions like anaphylaxis or Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they notice signs such as black stools, sudden swelling, chest pain, or severe rash.

Ketoprofen should be avoided by individuals with a known hypersensitivity to ketoprofen or other NSAIDs, those with active gastrointestinal ulceration or bleeding, severe heart failure, uncontrolled hypertension, and patients in the third trimester of pregnancy. It is also contraindicated in patients taking certain anticoagulants without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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