Product image of Ketoprofen Ziaja (Ketoprofen) supplied by GNH India

Ketoprofen Ziaja

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoprofen Ziaja (Ketoprofen)

Ketoprofen, the active ingredient in Ketoprofen Ziaja, is a nonsteroidal anti‑inflammatory drug (NSAID) presented as a topical gel for cutaneous use. It is employed to relieve pain and reduce inflammation in musculoskeletal conditions.
GNH India supplies Ketoprofen Ziaja as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ziaja Ltd. Zakład Produkcji Leków Sp. Z O.O.

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Indications & Clinical Uses

Ketoprofen Ziaja acts locally on inflammatory pathways to provide analgesic and anti‑inflammatory effects.

  • Osteoarthritis: reduces joint pain and swelling, improving mobility.
  • Rheumatoid arthritis flare‑ups: alleviates localized inflammation and discomfort.
  • Soft‑tissue injuries (sprains, strains, bruises): diminishes pain and accelerates recovery of the affected area.

How It Works

  • Ketoprofen inhibits cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes in peripheral tissues, leading to decreased synthesis of prostaglandins that mediate pain, fever, and inflammation. By limiting prostaglandin production at the site of application, the drug provides localized analgesic and anti‑inflammatory effects without significant systemic exposure.

Side Effects

Ketoprofen Ziaja may cause a range of skin‑related reactions when applied topically.

Common Side Effects

  • Skin irritation: mild redness or itching at the application site.
  • Burning sensation: transient warmth or tingling after use.
  • Dryness: localized dryness or flaking of the skin.
  • Pruritus: occasional itching unrelated to irritation.

Serious or Rare Side Effects

  • Severe allergic reaction: hives, swelling, or difficulty breathing.
  • Contact dermatitis: intense rash, blistering, or swelling.
  • Systemic NSAID effects: rare gastrointestinal upset if absorbed in large amounts.
  • Photosensitivity: heightened skin reaction to sunlight.

Precautions & Warnings

When using Ketoprofen Ziaja, consider the following safety measures.

  • Contraindications: avoid use on patients with known hypersensitivity to ketoprofen or other NSAIDs.
  • Skin integrity: do not apply to broken, infected, or severely damaged skin.
  • Duration: limit continuous use to the period recommended by a healthcare professional.
  • Concomitant NSAIDs: avoid simultaneous use of other topical or systemic NSAIDs to reduce cumulative risk.
  • Pregnancy & lactation: use only if clearly indicated and prescribed by a qualified practitioner.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct heat.

Avoid Interactions

Ketoprofen Ziaja can interact with other medicines, especially those affecting bleeding or renal function.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased risk of bleeding.
  • Systemic NSAIDs: additive gastrointestinal and renal toxicity.
  • Corticosteroids: heightened potential for skin ulceration.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or diuretics: possible reduction in renal perfusion.
  • Lithium: NSAIDs may raise serum lithium levels.
  • Methotrexate: potential for increased toxicity when combined with NSAIDs.

Frequently Asked Questions

Ketoprofen Ziaja is a topical NSAID applied to the skin to relieve pain and reduce inflammation associated with osteoarthritis, rheumatoid arthritis flare‑ups, and soft‑tissue injuries such as sprains, strains, and bruises.

Ketoprofen blocks the cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in the skin and underlying tissues, which lowers prostaglandin production. This reduction diminishes the signals that cause pain, swelling, and inflammation at the site of application.

The specific amount and frequency of application are determined by the prescribing healthcare professional based on the patient’s condition, age, and response to therapy. Patients should follow the prescriber’s instructions and the product label.

Ketoprofen should be used during pregnancy or while breastfeeding only if clearly indicated by a qualified clinician. The potential risks to the fetus or infant must be weighed against the therapeutic benefits, and alternative treatments may be preferred.

Enquiries can be submitted on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Ketoprofen Ziaja offers a potent COX‑inhibiting profile similar to other topical NSAIDs such as diclofenac gel, but it may provide faster onset of pain relief for certain musculoskeletal conditions. Choice of product often depends on clinician preference, patient tolerance, and specific formulation characteristics.

Store Ketoprofen Ziaja at ambient temperature, preferably below 25 °C. Keep the tube in its original packaging, protect it from moisture, direct sunlight, and excessive heat to maintain product stability.

The gel should be applied to clean, dry skin over the affected area, using a thin layer as directed by the prescriber. Gently rub it in until fully absorbed, and wash hands after application to avoid accidental contact with eyes or mucous membranes.

Serious risks include severe allergic reactions such as anaphylaxis, extensive contact dermatitis, and, in rare cases, systemic NSAID effects like gastrointestinal bleeding if significant absorption occurs. Patients should seek immediate medical attention if they experience swelling, difficulty breathing, or a widespread rash.

Individuals with known hypersensitivity to ketoprofen, other NSAIDs, or any component of the gel should avoid its use. It is also contraindicated on broken, infected, or severely damaged skin, and should be used with caution in patients with a history of asthma, renal impairment, or cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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