Ketoprofene Aguettant (Ketoprofen)

Ketoprofen is an NSAID that reduces inflammation and pain by inhibiting cyclooxygenase enzymes.

• Postoperative pain: provides analgesia and attenuates inflammatory response after surgical procedures.
• Rheumatoid arthritis: helps control joint inflammation and pain in chronic inflammatory disease.
• Acute musculoskeletal pain: relieves pain and swelling associated with sprains, strains or trauma.
• Inflammatory conditions: reduces swelling and discomfort in various acute inflammatory states.

• Ketoprofen exerts its effect by non‑selectively inhibiting cyclooxygenase‑1 (COX‑1) and cyclooxygenase‑2 (COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. The resulting decrease in prostaglandin synthesis diminishes inflammation, pain signaling, and fever responses at the site of tissue injury.

Ketoprofene Aguettant may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

• Nausea: mild to moderate stomach upset experienced after infusion.
• Dyspepsia: indigestion or heartburn that may persist for several hours.
• Headache: transient cranial discomfort often resolving without intervention.
• Injection site pain: local discomfort or mild irritation at the infusion site.

Serious or Rare Side Effects

• Gastrointestinal bleeding: potentially life‑threatening hemorrhage from the stomach or intestines.
• Renal impairment: reduced kidney function that can progress to failure if untreated.
• Severe allergic reaction: anaphylaxis, skin rash or angioedema requiring immediate medical care.
• Hepatic dysfunction: elevated liver enzymes or hepatitis presenting with jaundice or fatigue.

Before initiating therapy, clinicians should evaluate patient‑specific risk factors and follow safety guidelines.

• Assess renal function: evaluate kidney status prior to and during treatment.
• Monitor gastrointestinal risk: consider ulcer history and use gastro‑protective agents when appropriate.
• Evaluate cardiovascular history: avoid in patients with uncontrolled hypertension or recent cardiac events.
• Use lowest effective dose: limit duration to reduce the likelihood of adverse events.
• Avoid in known hypersensitivity: discontinue immediately if allergic signs appear.
• Store at room temperature: keep in the original container, protect from moisture and light.

Ketoprofene Aguettant can alter the activity of several concomitant medicines; interactions are classified by clinical significance.

Major Interactions (Avoid)

• Anticoagulants (e.g., warfarin): increased risk of serious bleeding.
• Other NSAIDs or aspirin: additive gastrointestinal toxicity and ulcer risk.
• Corticosteroids: heightened potential for ulceration and bleeding.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or ARBs: may reduce renal function when combined.
• Diuretics: potential for decreased kidney perfusion and electrolyte imbalance.
• Methotrexate: reduced clearance can lead to toxicity.