Product image of Ketoprofene Aguettant (Ketoprofen) supplied by GNH India

Ketoprofene Aguettant

Active Ingredient:
Ketoprofen
Origin:
EU

Ketoprofene Aguettant (Ketoprofen)

Ketoprofen, the active ingredient in Ketoprofene Aguettant, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an injectable solution for intravenous use. It is employed to relieve pain, reduce inflammation, and lower fever in patients with musculoskeletal disorders and other acute inflammatory conditions.

GNH India supplies Ketoprofene Aguettant as a licensed, GDP‑compliant international pharmaceutical product serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation to support safe import and clinical use through its global distribution network.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Ketoprofen is indicated for several inflammatory and pain‑related conditions, acting primarily on musculoskeletal and febrile disorders.

  • Pain: Provides analgesic relief in acute and chronic pain conditions.
  • Inflammation: Reduces inflammatory response in musculoskeletal and postoperative settings.
  • Fever: Lowers elevated body temperature associated with inflammatory processes.
  • Rheumatoid arthritis: Alleviates joint pain and swelling in rheumatoid arthritis.

How It Works

  • Ketoprofen inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes, which blocks the conversion of arachidonic acid to prostaglandins. By decreasing prostaglandin synthesis, it reduces the inflammatory cascade, leading to diminished pain, swelling, and fever at the site of tissue injury.

Side Effects

Ketoprofen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Gastrointestinal discomfort: nausea, dyspepsia, or abdominal pain.
  • Headache: mild to moderate intensity.
  • Dizziness or vertigo.
  • Injection‑site pain or erythema.
  • Mild rash or pruritus.
  • Transient elevation of liver enzymes.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Acute renal impairment or failure.
  • Severe hypersensitivity reactions, including anaphylaxis.
  • Hepatotoxicity with marked liver enzyme rise.
  • Cardiovascular events such as myocardial infarction.
  • Blood dyscrasias, including thrombocytopenia.

Precautions & Warnings

When using Ketoprofen, clinicians should consider several safety measures.

  • Renal function: assess baseline renal status and monitor during therapy.
  • Cardiovascular risk: use cautiously in patients with known heart disease.
  • Bleeding risk: avoid in individuals with active peptic ulcer or coagulopathy.
  • Pregnancy and lactation: prescribe only if benefit outweighs potential risk; safety data are limited.
  • Drug interactions: review concomitant medications for possible NSAID‑related interactions.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Ketoprofen can interact with a variety of medicines; some require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened ulcer risk.
  • ACE inhibitors or ARBs: potential for renal function decline.
  • Lithium: elevated lithium levels.

Moderate Interactions (Monitor Closely)

  • Diuretics: possible reduction in renal clearance.
  • Methotrexate: decreased elimination leading to toxicity.
  • Antihypertensives: may blunt blood pressure control.
  • SSRIs: modest increase in bleeding tendency.
  • Oral hypoglycemics: potential alteration of glucose control.

Frequently Asked Questions

Ketoprofene Aguettant is used to manage moderate to severe pain, reduce inflammation, and lower fever associated with musculoskeletal disorders, postoperative inflammation, rheumatoid arthritis, and other acute inflammatory conditions.

Ketoprofen blocks the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin levels, it diminishes the inflammatory response, providing analgesic, antipyretic, and anti‑inflammatory effects.

The specific dose and infusion rate are determined by the prescribing clinician based on the patient’s condition, weight, renal function, and response to therapy. Dosage adjustments are made according to clinical judgment and local guidelines.

Safety data for ketoprofen in pregnancy and lactation are limited. It should only be used when the potential benefit justifies the possible risk to the fetus or infant, and the decision must be made by the treating physician.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Ketoprofen offers a potent COX inhibition profile similar to other strong NSAIDs such as diclofenac or ibuprofen, but it may provide faster analgesia when given intravenously. Choice of agent depends on clinical context, patient tolerance, and specific safety considerations.

The injectable solution should be stored refrigerated at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability.

Ketoprofene Aguettant is administered by intravenous infusion under the supervision of a qualified healthcare professional. The infusion rate and total volume are set by the prescriber, and the solution should be administered using aseptic technique.

Serious adverse events include gastrointestinal ulceration or bleeding, acute renal failure, severe hypersensitivity reactions such as anaphylaxis, and cardiovascular complications like myocardial infarction. Patients should be monitored closely for these signs, especially if they have pre‑existing risk factors.

Ketoprofene Aguettant is contraindicated in patients with known hypersensitivity to ketoprofen or other NSAIDs, active gastrointestinal bleeding or ulcer, severe renal or hepatic impairment, and in those receiving anticoagulant therapy where bleeding risk is unacceptable.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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