Ketoprofene Benta (Ketoprofen)

Ketoprofen is a topical NSAID that acts on inflammatory pathways in the musculoskeletal system.

• Osteoarthritis: reduces joint pain and improves functional mobility.
• Rheumatoid arthritis: alleviates joint swelling and stiffness.
• Sprains, strains and back pain: provides localized analgesia and decreases inflammation.
• Musculoskeletal pain: offers rapid relief of aches in muscles and tendons.
• Inflammation of joints, muscles, tendons and bursae: diminishes swelling and discomfort.

• Ketoprofen reversibly inhibits cyclooxygenase‑1 and cyclooxygenase‑2 enzymes in peripheral tissues, blocking the conversion of arachidonic acid to prostaglandins. The reduced prostaglandin synthesis limits inflammation, pain signaling, and edema at the site of application, providing localized therapeutic effect without significant systemic exposure when used topically.

Ketoprofen may cause local and systemic adverse reactions, most of which are mild and reversible.

Common Side Effects

• Skin irritation or redness at the application site.
• Itching or burning sensation.
• Dryness or peeling of the skin.
• Mild itching or rash.
• Localized swelling.

Serious or Rare Side Effects

• Severe allergic reactions such as angioedema or anaphylaxis.
• Rare skin disorders like Stevens‑Johnson syndrome or toxic epidermal necrolysis.
• Systemic gastrointestinal ulceration or bleeding.
• Renal impairment or decreased kidney function.
• Hepatic dysfunction or elevated liver enzymes.
• Cardiovascular events such as hypertension or thrombotic episodes.

Before using Ketoprofene Benta, consider the following safety measures.

• Hypersensitivity: avoid if the patient has known allergy to ketoprofen or other NSAIDs.
• Peptic ulcer disease: contraindicated in active gastrointestinal ulceration.
• Renal or hepatic impairment: use with caution and monitor organ function.
• Concomitant topical NSAIDs: do not apply multiple NSAID products to the same area.
• Systemic absorption: monitor for signs of systemic NSAID effects, especially with extensive skin application.
• Store at room temperature: keep in the original container, protect from moisture and direct heat.

Ketoprofene Benta can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

• Oral anticoagulants (e.g., warfarin): increased risk of bleeding.
• Systemic NSAIDs or aspirin: heightened gastrointestinal and renal toxicity.
• Lithium: enhanced lithium serum levels.

Moderate Interactions (Monitor Closely)

• ACE inhibitors or diuretics: possible reduction in renal function.
• Selective serotonin reuptake inhibitors (SSRIs): may increase bleeding tendency.
• Alcohol: can exacerbate gastrointestinal irritation.